Edetate Calcium Disodium Calcium EDTA Brand Name– Calcium Disodium Versenate
What is Edetate Calcium Disodium Calcium EDTA
Edetate calcium disodium or calcium EDTA, is a parenteral drug used in the treatment of lead toxicity.
It should not be confused with the noncalcium-containing salt (edetate disodium), which is used to treat hypercalcemia.
Calcium EDTA reduces blood concentrations and depot stores of lead, and although it is used primarily in the treatment of lead poisoning, calcium EDTA also can be used as an antidote for other metal intoxications.
Calcium EDTA was approved by the FDA for clinical use in 1953.
Indications
- lead toxicity
For the treatment of lead toxicity
for the diagnosis of lead toxicity in patients with a blood lead concentration of 25 to 45 mcg/dL (i.e., the calcium EDTA mobilization test)
Side Effects
- anemia
- anorexia
- anuria
- cheilitis
- chills
- fatigue
- fever
- glycosuria
- headache
- hematuria
- hypercalcemia
- hypotension
- increased intracranial pressure
- lacrimation
- malaise
- myalgia
- nasal congestion
- nausea
- oliguria
- polydipsia
- proteinuria
- rash
- renal tubular necrosis
- sneezing
- tremor
- vomiting
- zinc deficiency
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- anuria
- breast-feeding
- children
- encephalopathy
- hepatitis
- increased intracranial pressure
- intravenous administration
- oliguria
- pregnancy
- renal disease
Interactions
- Calcium
- Calcium Acetate
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Calcium Chloride
- Calcium Gluconate
- Calcium; Vitamin D
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Cardiac glycosides
- Chlorpheniramine; Pseudoephedrine
- Chromium
- Digitoxin
- Digoxin
- Hetastarch; Dextrose; Electrolytes
- Insulins
- Magnesium
- Magnesium Citrate
- Magnesium Salts
- Succimer
- Zinc
- Zinc Salts
