Duvelisib Brand Name– Copiktra
What is Duvelisib
Duvelisib is a phosphatidylinositol-3-kinase (PI3K) inhibitor.
It was granted accelerated approval by the FDA for the treatment of adult patients with relapsed or refractory chronic lymphocytic leukemia/small lymphocytic lymphoma or follicular lymphoma who have received at least 2 prior therapies. Serious infection, diarrhea/colitis, cutaneous reactions, and pneumonitis have been reported with duvelisib therapy
Indications
- chronic lymphocytic leukemia (CLL)
- non-Hodgkin’s lymphoma (NHL)
- small lymphocytic lymphoma (SLL)
For the treatment of chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL)
NOTE: Duvelisib has been designated by the FDA as an orphan drug for the treatment of CLL and SLL.
for the treatment of relapsed or refractory CLL and SLL in patients who have received at least 2 prior therapies
Side Effects
- abdominal pain
- anemia
- anorexia
- arthralgia
- colitis
- constipation
- contact dermatitis
- cough
- diarrhea
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dyspnea
- edema
- elevated hepatic enzyme
- erythema
- erythema multiforme
- exfoliative dermatitis
- fatigue
- fever
- headache
- hyperamylasemia
- hyperkalemia
- hypoalbuminemia
- hypocalcemia
- hypokalemia
- hyponatremia
- hypophosphatemia
- infection
- leukopenia
- lymphocytosis
- lymphopenia
- maculopapular rash
- musculoskeletal pain
- nausea
- nephrotoxicity
- neutropenia
- oral ulceration
- pneumonitis
- rash
- Stevens-Johnson syndrome
- thrombocytopenia
- toxic epidermal necrolysis
- vomiting
- weight loss
Monitoring Parameters
- CBC with differential
- CD4+ T cell count
- LFTs
- pregnancy testing
Contraindications
- breast-feeding
- colitis
- contraception requirements
- diarrhea
- hepatotoxicity
- infection
- infertility
- male-mediated teratogenicity
- neutropenia
- pneumonitis
- pregnancy
- pregnancy testing
- reproductive risk
- serious rash
- thrombocytopenia
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abemaciclib
- Acalabrutinib
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Alfentanil
- Alfuzosin
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Amiodarone
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Aprepitant, Fosaprepitant
- Artemether; Lumefantrine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Avapritinib
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bosentan
- Bosutinib
- Brigatinib
- Bromocriptine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Buspirone
- Cannabidiol
- Carbamazepine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Ceritinib
- Chloramphenicol
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cilostazol
- Ciprofloxacin
- Clarithromycin
- Clozapine
- Cobicistat
- Cobimetinib
- Colchicine
- Colchicine; Probenecid
- Conivaptan
- Crizotinib
- Cyclosporine
- Danazol
- Darifenacin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Deflazacort
- Delavirdine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Dofetilide
- Dolutegravir
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Doxorubicin
- Dronabinol
- Dronedarone
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enalapril; Felodipine
- Encorafenib
- Entrectinib
- Enzalutamide
- Eplerenone
- Erythromycin
- Erythromycin; Sulfisoxazole
- Etravirine
- Everolimus
- Ezetimibe; Simvastatin
- Fedratinib
- Felodipine
- Fentanyl
- Flibanserin
- Fluconazole
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibrutinib
- Ibuprofen; Oxycodone
- Idelalisib
- Ifosfamide
- Imatinib
- Indinavir
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isradipine
- Itraconazole
- Ivacaftor
- Ivosidenib
- Ixabepilone
- Ketoconazole
- Lefamulin
- Lemborexant
- Letermovir
- Lomitapide
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Lurbinectedin
- Maraviroc
- Midazolam
- Mifepristone
- Mitotane
- Naldemedine
- Naloxegol
- Nanoparticle Albumin-Bound Paclitaxel
- Nefazodone
- Nelfinavir
- Neratinib
- Netupitant, Fosnetupitant; Palonosetron
- Niacin; Simvastatin
- Nilotinib
- Nimodipine
- Nisoldipine
- Olaparib
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Oxycodone
- Paclitaxel
- Pemigatinib
- Perindopril; Amlodipine
- Pexidartinib
- Phenobarbital
- Phenytoin
- Posaconazole
- Primidone
- Propafenone
- Quetiapine
- Quinine
- Ranolazine
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rimegepant
- Ritonavir
- Saquinavir
- Segesterone Acetate; Ethinyl Estradiol
- Selpercatinib
- Selumetinib
- Sildenafil
- Silodosin
- Simvastatin
- Simvastatin; Sitagliptin
- Siponimod
- Sirolimus
- Sonidegib
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Tacrolimus
- Tazemetostat
- Telithromycin
- Tezacaftor; Ivacaftor
- Ticagrelor
- Tipranavir
- Tolvaptan
- Trandolapril; Verapamil
- Triazolam
- Tucatinib
- Ubrogepant
- Vardenafil
- Venetoclax
- Verapamil
- Vinblastine
- Vinorelbine
- Voriconazole
- Zanubrutinib
- Zolpidem
