Dupilumab Brand Name– DUPIXENT
What is Dupilumab
Dupilumab an interleukin-4 receptor alpha antagonist, is a human monoclonal antibody of the IgG4 subclass.
It is used subcutaneously and has utility in allergic-mediated diseases such as eczema, asthma, and nasal polyps due to chronic sinusitis.
The drug is indicated for the treatment of adult and pediatric patients 6 years and older with moderate-to-severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable; dupilumab may be used with or without topical corticosteroids.
The drug is also indicated as add-on maintenance therapy in patients 12 years and older with an eosinophilic phenotype or oral corticosteroid-dependent moderate-to-severe asthma.
It is not indicated for the relief of acute bronchospasm or status asthmaticus.
Dupilumab is also approved as maintenance treatment in adult patients with inadequately controlled chronic rhinosinusitis with nasal polyposis (CRSwNP).
Indications
- asthma maintenance
- atopic dermatitis
- nasal polyps
- sinusitis
For the treatment of moderate-to-severe atopic dermatitis in patients whose disease is not adequately controlled with topical therapies or when those therapies are not advised
Side Effects
- antibody formation
- arthralgia
- blepharitis
- conjunctivitis
- dental pain
- eosinophilia
- erythema nodosum
- exfoliative dermatitis
- gastritis
- infection
- injection site reaction
- insomnia
- keratitis
- myocardial infarction
- ocular pruritus
- rash
- serious hypersensitivity reactions or anaphylaxis
- serum sickness
- stroke
- thromboembolism
- urticaria
- xerophthalmia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- acute bronchospasm
- asthma
- breast-feeding
- corticosteroid withdrawal
- eosinophilic pneumonia
- helminth infection
- pregnancy
- status asthmaticus
- vaccination
- vasculitis
Interactions
- Bacillus Calmette-Guerin Vaccine, BCG
- Carbamazepine
- Cyclosporine
- Digoxin
- Ethosuximide
- Fosphenytoin
- Influenza Virus Vaccine
- Intranasal Influenza Vaccine
- Lithium
- Live Vaccines
- Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
- Measles/Mumps/Rubella Vaccines, MMR
- Phenytoin
- Procainamide
- Rotavirus Vaccine
- Rubella Virus Vaccine Live
- Smallpox and Monkeypox Vaccine, Live, Nonreplicating
- Smallpox Vaccine, Vaccinia Vaccine
- Tacrolimus
- Theophylline, Aminophylline
- Typhoid Vaccine
- Varicella-Zoster Virus Vaccine, Live
- Warfarin
- Yellow Fever Vaccine, Live
