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Doxorubicin Brand Names
Adriamycin | Adriamycin PFS | Adriamycin RDF | Rubex
What is Doxorubicin
Doxorubicin is a cytotoxic anthracycline antibiotic that inhibits nucleotide replication by intercalation into DNA and RNA; it is also a topoisomerase II inhibitor.
Doxorubicin is indicated for the treatment of acute lymphoblastic leukemia, acute myeloblastic leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, metastatic breast cancer, metastatic Wilms’ tumor, metastatic neuroblastoma, metastatic soft tissue sarcoma, metastatic bone sarcoma, metastatic ovarian cancer, metastatic transitional cell bladder cancer, metastatic thyroid cancer, metastatic gastric cancer, and metastatic lung cancer; it is also indicated for the adjuvant treatment of breast cancer.
Indications
- acute lymphocytic leukemia (ALL)
- acute myelogenous leukemia (AML)
- biliary tract cancer
- bladder cancer
- breast cancer
- endometrial cancer
- Ewing’s sarcoma
- gastric cancer
- hepatocellular cancer
- Hodgkin lymphoma
- Kaposi’s sarcoma
- malignant melanoma
- multiple myeloma
- neuroblastoma
- non-Hodgkin’s lymphoma (NHL)
- osteogenic sarcoma
- ovarian cancer
- peripheral T-cell lymphoma (PTCL)
- rhabdomyosarcoma
- small cell lung cancer (SCLC)
- soft-tissue sarcoma
- systemic anaplastic large-cell lymphoma
- thymoma
- thyroid cancer
- Wilms’ tumor
Side Effects
- abdominal pain
- alopecia
- amenorrhea
- anaphylactoid reactions
- anorexia
- asthenia
- azoospermia
- bleeding
- bone marrow suppression
- cardiomyopathy
- cardiotoxicity
- chills
- Co-Enzyme Q-10 deficiency
- colitis
- coma
- conjunctivitis
- dehydration
- diarrhea
- elevated hepatic enzymes
- erythema
- esophagitis
- fever
- GI bleeding
- gonadal suppression
- growth inhibition
- heart failure
- infection
- injection site reaction
- keratitis
- lacrimation
- leukopenia
- leukopenia
- malaise
- myocarditis
- nail discoloration
- nausea
- neutropenia
- new primary malignancy
- oligospermia
- onycholysis
- oral ulceration
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- peptic ulcer
- pericarditis
- peripheral neuropathy
- phlebitis
- photosensitivity
- pruritus
- radiation recall reaction
- rash
- seizures
- skin hyperpigmentation
- skin ulcer
- spermatogenesis inhibition
- stomatitis
- thrombocytopenia
- thrombocytopenia
- tissue necrosis
- tumor lysis syndrome (TLS)
- typhlitis
- urine discoloration
- urticaria
- vomiting
- weight gain
Monitoring Parameters
- CBC with differential
- echocardiogram
- LFTs
- multi-gated radionuclide angiography (MUGA)
- serum bilirubin
- serum creatinine/BUN
- serum electrolytes
- serum uric acid
Contraindications
- anthracycline hypersensitivity
- bone marrow suppression
- breast-feeding
- cardiomyopathy
- cardiotoxicity
- children
- contraception requirements
- extravasation
- females
- growth inhibition
- heart failure
- hepatic disease
- infants
- infection
- infertility
- leukopenia
- male-mediated teratogenicity
- maximum cumulative lifetime dose
- myocardial infarction
- myocarditis
- neutropenia
- new primary malignancy
- pericarditis
- pregnancy
- radiation therapy
- reproductive risk
- thrombocytopenia
- tissue necrosis
- tumor lysis syndrome (TLS)
- vaccination
Interactions
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Abiraterone
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Diphenhydramine
- Amiodarone
- Amlodipine; Celecoxib
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Aprepitant, Fosaprepitant
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bexarotene
- Boceprevir
- Bosentan
- Bosutinib
- Brigatinib
- Bupropion
- Bupropion; Naltrexone
- Butabarbital
- Cabozantinib
- Capmatinib
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carvedilol
- Celecoxib
- Cenobamate
- Ceritinib
- Chloramphenicol
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Cimetidine
- Cinacalcet
- Ciprofloxacin
- Clarithromycin
- Clobazam
- Cobicistat
- Cocaine
- Conivaptan
- Crizotinib
- Cyclophosphamide
- Cyclosporine
- Dabrafenib
- Daclatasvir
- Daclizumab
- Dacomitinib
- Dalfopristin; Quinupristin
- Danazol
- Darifenacin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Dexrazoxane
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Quinidine
- Diltiazem
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Docetaxel
- Dronedarone
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elbasvir; Grazoprevir
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enzalutamide
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Eslicarbazepine
- Estradiol; Progesterone
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethotoin
- Etravirine
- Fedratinib
- Felbamate
- Fluconazole
- Flutamide
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- Fostamatinib
- Gadobenate Dimeglumine
- Ganciclovir
- Glecaprevir; Pibrentasvir
- grapefruit juice
- Hydantoins
- Idelalisib
- Imatinib
- Indinavir
- Isavuconazonium
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Istradefylline
- Itraconazole
- Ivacaftor
- Ixabepilone
- Ketoconazole
- Lamivudine, 3TC; Zidovudine, ZDV
- Lapatinib
- Larotrectinib
- Ledipasvir; Sofosbuvir
- Lefamulin
- Letermovir
- Lopinavir; Ritonavir
- Lorcaserin
- Lorlatinib
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Mephobarbital
- Mercaptopurine, 6-MP
- Methohexital
- Mifepristone
- Mirabegron
- Mitotane
- Modafinil
- Mycophenolate
- Nafcillin
- Nefazodone
- Nelfinavir
- Neratinib
- Nevirapine
- Nicardipine
- Nicotine
- Nilotinib
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Oritavancin
- Osimertinib
- Oxcarbazepine
- Paclitaxel
- Palbociclib
- Palifermin
- Paroxetine
- Pazopanib
- Peginterferon Alfa-2b
- Penicillamine
- Pentobarbital
- Perampanel
- Phenobarbital
- Phentermine; Topiramate
- Phenytoin
- Posaconazole
- Primidone
- Progesterone
- Propafenone
- Quinidine
- Quinine
- Ranolazine
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifaximin
- Ritonavir
- Rolapitant
- Rucaparib
- Sapropterin
- Saquinavir
- Sarecycline
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Simeprevir
- Sirolimus
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Sorafenib
- St. John’s Wort, Hypericum perforatum
- Stavudine, d4T
- Streptogramins
- Streptozocin
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Temsirolimus
- Tezacaftor; Ivacaftor
- Thiopental
- Thioridazine
- Thiothixene
- Tipranavir
- Topiramate
- Trandolapril; Verapamil
- Trastuzumab
- Trastuzumab; Hyaluronidase
- Tuberculin Purified Protein Derivative, PPD
- Tucatinib
- Valganciclovir
- Valproic Acid, Divalproex Sodium
- Vemurafenib
- Verapamil
- Voriconazole
- Zafirlukast
- Zalcitabine, ddC
- Zidovudine, ZDV
- Zonisamide
