What's on this Page
Doxazosin Brand Names- Cardura | Cardura XL
What is Doxazosin
Doxazosin is an oral, alpha-adrenergic blocking agent used in the treatment of hypertension and for benign prostatic hyperplasia.
It is pharmacologically similar to prazosin and terazosin but has the longest duration of action of the group. Doxazosin is a potent, long-acting antihypertensive with minimal adverse reactions.
It can be dosed once daily. A recent landmark clinical trial (ALLHAT) compared doxazosin to chlorthalidone in the treatment of high-risk hypertensive patients.
In this study, only the diuretic significantly reduced the risk of combined cardiovascular disease events, especially heart failure; whereas doxazosin did not.
These results led to discontinuation of the doxazosin treatment arm of the study.
Doxazosin was originally approved by the FDA in November 1990 for the treatment of hypertension and was subsequently approved for the treatment of BPH in April 1995.
Indications
- benign prostatic hyperplasia (BPH)
- hypertension
For treatment of hypertension
Side Effects
- abdominal pain
- agitation
- alopecia
- anorexia
- anxiety
- arthralgia
- asthenia
- ataxia
- blurred vision
- bradycardia
- bronchospasm
- chest pain (unspecified)
- cholestasis
- diarrhea
- dizziness
- drowsiness
- dyspepsia
- dyspnea
- edema
- elevated hepatic enzymes
- epistaxis
- fatigue
- floppy iris syndrome
- flushing
- gynecomastia
- headache
- hematuria
- hepatitis
- hyperhidrosis
- hypertonia
- hypoesthesia
- hypotension
- impotence (erectile dysfunction)
- increased urinary frequency
- infection
- influenza
- insomnia
- jaundice
- leukopenia
- libido decrease
- malaise
- muscle cramps
- myalgia
- myasthenia
- myocardial infarction
- nausea
- nocturia
- orthostatic hypotension
- palpitations
- paresthesias
- polyuria
- priapism
- pruritus
- purpura
- rash
- rhinitis
- sinus tachycardia
- stroke
- syncope
- thrombocytopenia
- tinnitus
- urinary incontinence
- urticaria
- vertigo
- visual impairment
- vomiting
- xerostomia
Monitoring Parameters
- blood pressure
- heart rate
Contraindications
- breast-feeding
- geriatric
- hepatic disease
- hypotension
- ocular surgery
- orthostatic hypotension
- pregnancy
- priapism
- syncope
Interactions
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alemtuzumab
- Alfuzosin
- Alprostadil
- Amifostine
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamines
- Amyl Nitrite
- Apomorphine
- Apraclonidine
- Aripiprazole
- Articaine; Epinephrine
- Asenapine
- Atazanavir
- Atazanavir; Cobicistat
- Avanafil
- Baclofen
- Beta-blockers
- Boceprevir
- Bortezomib
- Bosentan
- Brexpiprazole
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Cabergoline
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloramphenicol
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Clarithromycin
- Clozapine
- Co-Enzyme Q10, Ubiquinone
- Cobicistat
- Codeine; Phenylephrine; Promethazine
- Conivaptan
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Quinidine
- Diazoxide
- Diethylpropion
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Dobutamine
- Dopamine
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Dutasteride; Tamsulosin
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enflurane
- Ephedrine
- Epinephrine
- Epoprostenol
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etomidate
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Fluoxetine; Olanzapine
- Fosamprenavir
- Fospropofol
- General anesthetics
- grapefruit juice
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Haloperidol
- Halothane
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Iloperidone
- Iloprost
- Indinavir
- Intravenous Lipid Emulsions
- Isocarboxazid
- Isoflurane
- Isoproterenol
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Itraconazole
- Ketamine
- Ketoconazole
- Levodopa
- Lofexidine
- Lopinavir; Ritonavir
- Loratadine; Pseudoephedrine
- Lovastatin; Niacin
- Lurasidone
- Mestranol; Norethindrone
- Methohexital
- Methylphenidate
- Midodrine
- Milrinone
- Naproxen; Pseudoephedrine
- Nefazodone
- Nelfinavir
- Nesiritide, BNP
- Niacin, Niacinamide
- Niacin; Simvastatin
- Nicotine
- Nitrates
- Nitroglycerin
- Nitroprusside
- Nonsteroidal antiinflammatory drugs
- Norepinephrine
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Oxymetazoline
- Paliperidone
- Pentoxifylline
- Phendimetrazine
- Phenelzine
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Posaconazole
- Prilocaine; Epinephrine
- Procainamide
- Procaine
- Propofol
- Pseudoephedrine
- Quinidine
- Rasagiline
- Risperidone
- Ritodrine
- Ritonavir
- Saquinavir
- Segesterone Acetate; Ethinyl Estradiol
- Selegiline
- Sevoflurane
- Sildenafil
- Silodosin
- Tadalafil
- Tamsulosin
- Telithromycin
- Tetrabenazine
- Tetracaine
- Thalidomide
- Thiopental
- Thiothixene
- Tipranavir
- Tizanidine
- Trandolapril; Verapamil
- Tranylcypromine
- Trazodone
- Vardenafil
- Verapamil
- Voriconazole
- Yohimbine
- Ziprasidone
