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Disopyramide Brand Name
What is Disopyramide
Disopyramide is an oral class IA antiarrhythmic agent. Disopyramide is similar to procainamide and quinidine in its pharmacologic action, but its significant anticholinergic properties often limit its use.
Disopyramide also has a significant negative inotropic effect, which is pronounced in patients with underlying abnormal left ventricular function.
The drug is only used in patients with life-threatening ventricular arrhythmia, due to its proarrhythmic potential. Initiation of disopyramide treatment should be carried out in the hospital.
Antiarrhythmic drugs have not been shown to enhance survival in patients with ventricular arrhythmias.
Indications
- atrial fibrillation
- atrial flutter
- ventricular tachycardia
For the treatment of documented, life-threatening arrhythmias such as sustained ventricular tachycardia
Side Effects
- abdominal pain
- agranulocytosis
- anemia
- angina
- anorexia
- arrhythmia exacerbation
- AV block
- blurred vision
- constipation
- depression
- diarrhea
- dizziness
- dyspnea
- dysuria
- edema
- elevated hepatic enzymes
- fatigue
- flatulence
- headache
- heart failure
- hypercholesterolemia
- hypertriglyceridemia
- hypoglycemia
- hypokalemia
- hypotension
- impotence (erectile dysfunction)
- increased urinary frequency
- insomnia
- jaundice
- malaise
- musculoskeletal pain
- nausea
- paresthesias
- pruritus
- QT prolongation
- rash
- syncope
- thrombocytopenia
- torsade de pointes
- urinary retention
- urinary urgency
- ventricular tachycardia
- vomiting
- weight gain
- xerosis
- xerostomia
Monitoring Parameters
- blood glucose
- ECG
- serum creatinine/BUN
- serum potassium
Contraindications
- anticholinergic medications
- apheresis
- AV block
- bladder obstruction
- bradycardia
- breast-feeding
- bundle-branch block
- cardiogenic shock
- cardiomyopathy
- celiac disease
- contact lenses
- diabetes mellitus
- females
- fever
- geriatric
- glaucoma
- heart failure
- hepatic disease
- human immunodeficiency virus (HIV) infection
- hyperkalemia
- hyperparathyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- long QT syndrome
- mortality
- myasthenia gravis
- myocardial infarction
- pheochromocytoma
- pregnancy
- prostatic hypertrophy
- QT prolongation
- renal disease
- renal failure
- renal impairment
- rheumatoid arthritis
- sick sinus syndrome
- sickle cell disease
- sleep deprivation
- stroke
- systemic lupus erythematosus (SLE)
- urinary retention
- ventricular arrhythmias
- Wolff-Parkinson-White syndrome
Interactions
- Abarelix
- Acarbose
- Acebutolol
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Pentazocine
- Albiglutide
- Alfuzosin
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alosetron
- Alpha-glucosidase Inhibitors
- Amantadine
- Ambenonium Chloride
- Amiodarone
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Anagrelide
- Anticholinergics
- Apalutamide
- Apomorphine
- Aprepitant, Fosaprepitant
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Caffeine; Orphenadrine
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atomoxetine
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azithromycin
- Barbiturates
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Bendroflumethiazide; Nadolol
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benztropine
- Bepridil
- Betaxolol
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol
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- Boceprevir
- Bosentan
- Brimonidine; Timolol
- Brompheniramine
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- Bupivacaine; Lidocaine
- Buprenorphine
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- Canagliflozin; Metformin
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
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- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
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- grapefruit juice
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- Halogenated Anesthetics
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- Halothane
- Histrelin
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- Hydrochlorothiazide, HCTZ; Metoprolol
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- Hydroxyzine
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- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
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- Levofloxacin
- Levomethadyl
- Lidocaine
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- Lithium
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- Metformin; Sitagliptin
- Methadone
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- Metreleptin
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