Diethylpropion

Diethylpropion Brand Names

Depletite # 2 | Durad | Radtue | Tenuate | Tenuate Dospan

What is Diethylpropion

Diethylpropion is an oral, centrally-acting stimulant and sympathomimetic amine that is pharmacologically related to amphetamines.

It is used in adults for the short-term management (i.e., a few weeks) of exogenous obesity in conjunction with lifestyle modifications; however, diethylpropion is not an agent of choice for weight loss in obese patients.

According to the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, short-term pharmacotherapy, such as with diethylpropion, has not been shown to produce longer-term health benefits in obese and overweight patients and cannot be generally recommended.

Diethylpropion should not be used for long-term weight management; tolerance to the anorectic effect of stimulants has been demonstrated.

Similar to amphetamines, diethylpropion is contraindicated in patients with a history of substance abuse because of abuse and addiction potential.

Due to a possible association between diethylpropion and valvular heart disease and pulmonary hypertension, a baseline cardiac evaluation should be considered prior to initiation of diethylpropion treatment.

Diethylpropion was initially approved for commercial clinical use in 1959.

Indications

• obesity

For the short-term (i.e., a few weeks) treatment of exogenous obesity

Side Effects

1. abdominal pain
2. agranulocytosis
3. alopecia
4. angina
5. anxiety
6. blurred vision
7. bradycardia
8. cardiac valvulopathy
9. chest pain (unspecified)
10. constipation
11. delirium
12. depression
13. diaphoresis
14. diarrhea
15. dizziness
16. drowsiness
17. dysgeusia
18. dyskinesia
19. dysphoria
20. dyspnea
21. dysuria
22. ecchymosis
23. erythema
24. euphoria
25. gynecomastia
26. hallucinations
27. headache
28. hyperhidrosis
29. hypertension
30. hypotension
31. impotence (erectile dysfunction)
32. insomnia
33. leukopenia
34. libido decrease
35. libido increase
36. malaise
37. menstrual irregularity
38. myalgia
39. mydriasis
40. nausea
41. palpitations
42. paranoia
43. physiological dependence
44. polyuria
45. psychological dependence
46. psychosis
47. pulmonary hypertension
48. rash
49. restlessness
50. rhabdomyolysis
51. seizures
52. sinus tachycardia
53. stroke
54. syncope
55. tachypnea
56. tolerance
57. torsade de pointes
58. tremor
59. urticaria
60. vomiting
61. withdrawal
62. xerostomia

Monitoring Parameters

• blood pressure
• heart rate
• weight

Contraindications

• abrupt discontinuation
• anorexia nervosa
• arteriosclerosis
• breast-feeding
• cardiac arrhythmias
• children
• geriatric
• glaucoma
• hypertension
• hyperthyroidism
• infants
• long QT syndrome
• mania
• MAOI therapy
• neonates
• pregnancy
• psychosis
• pulmonary hypertension
• renal failure
• renal impairment
• seizure disorder
• substance abuse
• surgery
• thyroid disease
• valvular heart disease

Interactions

• Acarbose
• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Guaifenesin; Phenylephrine
• Aclidinium; Formoterol
• Albiglutide
• Albuterol
• Albuterol; Ipratropium
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Alogliptin; Pioglitazone
• Alpha-blockers
• Alpha-glucosidase Inhibitors
• Amantadine
• Ambrisentan
• Amifampridine
• Amiloride; Hydrochlorothiazide, HCTZ
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Amoxapine
• Angiotensin II receptor antagonists
• Angiotensin-converting enzyme inhibitors
• Arformoterol
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Atenolol
• Atenolol; Chlorthalidone
• Atomoxetine
• Azilsartan; Chlorthalidone
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Beta-blockers
• Betaxolol
• Bethanechol
• Bisoprolol
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Bosentan
• Bretylium
• Brimonidine; Timolol
• Bromocriptine
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Dextromethorphan; Phenylephrine
• Budesonide; Formoterol
• Bupropion
• Bupropion; Naltrexone
• Cabergoline
• Caffeine
• Caffeine; Ergotamine
• Calcium-channel blockers
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan; Hydrochlorothiazide, HCTZ
• Captopril; Hydrochlorothiazide, HCTZ
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Phenylephrine
• Cardiac glycosides
• Carteolol
• Carvedilol
• Chlophedianol; Guaifenesin; Phenylephrine
• Chlorothiazide
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Phenylephrine
• Chlorpromazine
• Chlorthalidone
• Chlorthalidone; Clonidine
• Clevidipine
• Clomipramine
• Clonidine
• Cocaine
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• Colchicine
• Colchicine; Probenecid
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Desipramine
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Promethazine
• Digitoxin
• Digoxin
• Diltiazem
• Dipeptidyl Peptidase-4 Inhibitors
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Phenylephrine
• Dopamine
• Dorzolamide; Timolol
• Doxepin
• Dronabinol
• Droxidopa
• Dulaglutide
• Dyphylline
• Dyphylline; Guaifenesin
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Enflurane
• Ephedrine
• Eplerenone
• Epoprostenol
• Eprosartan; Hydrochlorothiazide, HCTZ
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Esketamine
• Esmolol
• Exenatide
• Felodipine
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluphenazine
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Formoterol
• Formoterol; Mometasone
• Fosinopril; Hydrochlorothiazide, HCTZ
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glycopyrrolate; Formoterol
• Green Tea
• Guaifenesin; Phenylephrine
• Guanabenz
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone; Phenylephrine
• Iloprost
• Imipramine
• Incretin Mimetics
• Indacaterol
• Indacaterol; Glycopyrrolate
• Indapamide
• Insulin Degludec; Liraglutide
• Insulin Glargine; Lixisenatide
• Insulins
• Iobenguane I 131
• Isocarboxazid
• Isradipine
• Labetalol
• Levalbuterol
• Levobetaxolol
• Levobunolol
• Levothyroxine
• Levothyroxine; Liothyronine (Porcine)
• Levothyroxine; Liothyronine (Synthetic)
• Linezolid
• Liothyronine
• Liraglutide
• Lixisenatide
• Loop diuretics
• Macitentan
• Maprotiline
• Mecamylamine
• Meglitinides
• Meperidine; Promethazine
• Mesoridazine
• Metaproterenol
• Metformin; Pioglitazone
• Metformin; Rosiglitazone
• Methyclothiazide
• Methyldopa
• Metolazone
• Metoprolol
• Midodrine
• Miglitol
• Monoamine oxidase inhibitors
• Nabilone
• Nadolol
• Nebivolol
• Nebivolol; Valsartan
• Nicardipine
• Nifedipine
• Nimodipine
• Nisoldipine
• Nitrates
• Non-Ionic Contrast Media
• Norepinephrine
• Nortriptyline
• Ozanimod
• Penbutolol
• Perindopril; Amlodipine
• Perphenazine
• Perphenazine; Amitriptyline
• Phenelzine
• Phenothiazines
• Phenylephrine
• Phenylephrine; Promethazine
• Pindolol
• Pioglitazone
• Pirbuterol
• Pramlintide
• Procarbazine
• Prochlorperazine
• Promethazine
• Propranolol
• Protriptyline
• Rasagiline
• Reserpine
• Riociguat
• Rosiglitazone
• Safinamide
• Salmeterol
• Selegiline
• Selexipag
• Semaglutide
• SGLT2 Inhibitors
• Sibutramine
• Solriamfetol
• Sotalol
• St. John’s Wort, Hypericum perforatum
• Sulfonylureas
• Terbutaline
• Theophylline, Aminophylline
• Thiazide diuretics
• Thiazolidinediones
• Thiethylperazine
• Thioridazine
• Thyroid hormones
• Timolol
• Trandolapril; Verapamil
• Tranylcypromine
• Treprostinil
• Tricyclic antidepressants
• Trifluoperazine
• Trimipramine
• Umeclidinium; Vilanterol
• Vasodilators
• Vasopressors
• Verapamil
• Yohimbine