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Didanosine ddI Brand Names- Videx | Videx EC
What is Didanosine ddI
Didanosine is an oral nucleoside reverse transcriptase inhibitor (NRTI) indicated for use with other antiretroviral medications to treat HIV-1 infections.
It is an acid-labile drug which must be protected from stomach acids; thus, the powder for oral solution contains a buffering agent that, while improving didanosine bioavailability, is associated with several drug interactions.
Didanosine extended-release capsules contain enteric-coated beads of didanosine that dissolve after entering the small intestine; this formulation is associated with fewer drug interactions than the powder for oral solution, as it is not formulated with a buffering agent.
One of the major toxicities of didanosine is pancreatitis.
Indications
- hepatitis B virus
- human immunodeficiency virus (HIV)
- human immunodeficiency virus (HIV) infection
Side Effects
- abdominal pain
- alopecia
- anaphylactoid reactions
- anemia
- anorexia
- arthralgia
- ascites
- asthenia
- chills
- diabetes mellitus
- diarrhea
- dyspepsia
- elevated hepatic enzymes
- fever
- flatulence
- headache
- hematemesis
- hepatic failure
- hepatitis
- hepatomegaly
- hepatotoxicity
- hyperamylasemia
- hyperbilirubinemia
- hyperglycemia
- hyperuricemia
- hypoglycemia
- lactic acidosis
- leukopenia
- lipodystrophy
- myalgia
- myopathy
- nausea
- optic neuritis
- pancreatitis
- peripheral neuropathy
- pruritus
- rash
- renal failure (unspecified)
- retinal pigment changes
- rhabdomyolysis
- sialadenitis
- splenomegaly
- steatosis
- thrombocytopenia
- vomiting
- xerophthalmia
- xerostomia
Monitoring Parameters
- blood glucose
- CBC with differential
- CD4+ T cell count
- hepatitis B serology
- LFTs
- plasma hepatitis C RNA
- plasma HIV RNA
- pregnancy testing
- serum amylase
- serum bilirubin (total and direct)
- serum cholesterol
- serum creatinine/BUN
- serum lipid profile
- serum magnesium
- serum potassium
- serum uric acid
- urinalysis
Contraindications
- alcoholism
- autoimmune disease
- breast-feeding
- cardiac disease
- cholelithiasis
- dialysis
- females
- geriatric
- gout
- Graves’ disease
- Guillain-Barre syndrome
- hepatic disease
- hepatitis B and HIV coinfection
- hepatitis C and HIV coinfection
- hepatotoxicity or lactic acidosis
- human immunodeficiency virus (HIV) infection resistance
- hypertriglyceridemia
- hyperuricemia
- immune reconstitution syndrome
- myocardial infarction
- obesity
- pancreatitis
- peripheral neuropathy
- pregnancy
- renal failure
- renal impairment
Interactions
- Adefovir
- Allopurinol
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amprenavir
- Atazanavir
- Atazanavir; Cobicistat
- Bortezomib
- Calcium Carbonate; Magnesium Hydroxide
- Cefpodoxime
- Ceftibuten
- Ciprofloxacin
- Dapsone
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delafloxacin
- Delavirdine
- Dolutegravir; Rilpivirine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Echinacea
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir disoproxil fumarate
- food
- Fosamprenavir
- Ganciclovir
- Gemifloxacin
- Hydroxyurea
- Indinavir
- Interferon Alfa-2b; Ribavirin
- Iron
- Itraconazole
- Ketoconazole
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lesinurad; Allopurinol
- Levofloxacin
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Liothyronine
- Lomefloxacin
- Magnesium Hydroxide
- Methadone
- Moxifloxacin
- Nelfinavir
- Norfloxacin
- Ofloxacin
- Ombitasvir; Paritaprevir; Ritonavir
- Orlistat
- Pexidartinib
- Ribavirin
- Rilpivirine
- Riluzole
- Sparfloxacin
- Stavudine, d4T
- Tenofovir, PMPA
- Tetracyclines
- Thyroid hormones
- Tipranavir
- Trovafloxacin, Alatrofloxacin
- Valganciclovir
- Zalcitabine, ddC
