Dextromethorphan Promethazine Brand Name– Phen Tuss DM
What is Dextromethorphan Promethazine
Dextromethorphan and promethazine are used together in an oral liquid preparation to relieve cough and upper respiratory symptoms associated with allergy or the common cold.
Dextromethorphan is a centrally acting, non-narcotic antitussive agent.
Promethazine is a phenothiazine-structure sedating antihistamine (H-1 blocker) that dries the nasal and sinus passages.
There is a boxed warning against use in children and infants less than 2 years of age; postmarketing cases of respiratory depression, including fatalities, have been reported with use of promethazine in young pediatric patients.
Indications
- common cold
- cough
For the temporary relief of cough and upper respiratory symptoms associated with allergy or the common cold
Side Effects
- agitation
- agranulocytosis
- akathisia
- angioedema
- anxiety
- apnea
- blurred vision
- bradycardia
- cholestasis
- confusion
- constipation
- contact dermatitis
- delirium
- depression
- diplopia
- dizziness
- drowsiness
- dystonic reaction
- dysuria
- euphoria
- excitability
- fatigue
- fever
- hallucinations
- headache
- hepatitis
- hyperthermia
- hypothermia
- ileus
- impaired cognition
- impotence (erectile dysfunction)
- insomnia
- jaundice
- leukopenia
- mydriasis
- nasal congestion
- nausea
- neuroleptic malignant syndrome
- neutropenia
- nightmares
- ocular hypertension
- palpitations
- photosensitivity
- platelet dysfunction
- pseudoparkinsonism
- psychological dependence
- purpura
- rash
- respiratory depression
- restlessness
- seizures
- serotonin syndrome
- sinus tachycardia
- skin hyperpigmentation
- syncope
- tardive dyskinesia
- thrombocytopenia
- tinnitus
- torticollis
- tremor
- urinary retention
- urticaria
- vomiting
- weight gain
- xerophthalmia
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- agranulocytosis
- anticholinergic medications
- asthma
- atopy
- bladder obstruction
- bone marrow suppression
- breast-feeding
- cardiac disease
- children
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- CNS depression
- coadministration with other CNS depressants
- coma
- dehydration
- diabetes mellitus
- driving or operating machinery
- ethanol ingestion
- geriatric
- head trauma
- hepatic disease
- hepatic encephalopathy
- ileus
- increased intracranial pressure
- infants
- jaundice
- laboratory test interference
- MAOI therapy
- neonates
- neutropenia
- obstetric delivery
- peptic ulcer disease
- phenothiazine hypersensitivity
- pregnancy
- prostatic hypertrophy
- radiographic contrast administration
- respiratory depression
- Reye’s syndrome
- seizure disorder
- sleep apnea
- sunlight (UV) exposure
- urinary retention
Interactions
- Abarelix
- Abiraterone
- Acarbose
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
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- Chlorpheniramine; Hydrocodone
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