Dextromethorphan Guaifenesin Potassium Guaiacolsulfonate Brand Name– Humibid DM
What is Dextromethorphan Guaifenesin Potassium Guaiacolsulfonate
NOTE: These products are discontinued in the U.S.
Dextromethorphan guaifenesin potassium guaiacolsulfonate are used in combination to quiet coughs and produce expectoration.
Dextromethorphan is an oral non-opioid antitussive.
Dextromethorphan is used to treat chronic, nonproductive cough, but it has no expectorant activity. Guaifenesin and potassium guaiacolsulfonate are historically used as oral expectorants for dry, non-productive coughs.
An expert review in 1976 by the FDA noted that potassium guaiacolsulfonate was generally not effective as an expectorant.
TNew regulatory guidelines regarding expectorants were issued by the FDA in October 2003. In 2003, the Humibid DM product was reformulated to contain dextromethorphan; guaifenesin; potassium guaiacolsulfonate in a variable-release capsule formulation.
However, in March 2004, the FDA indicated that the reformulated product was being sold in violation of existing drug regulations; the drug combination was considered to be a new drug requiring proper regulatory approval prior to marketing.
As of December 2004, Humibid DM was no longer commercially available in the U.S.
Indications
- bronchitis
- common cold
- cough
For the temporary relief of cough and to ease expectoration due to upper respiratory tract disorders such as the common cold and chronic bronchitis when these conditions are complicated by tenacious mucus and/or mucus plugs and congestion
Side Effects
- abdominal pain
- confusion
- diarrhea
- dizziness
- drowsiness
- dysarthria
- hallucinations
- headache
- irritability
- nausea
- rash
- respiratory depression
- restlessness
- seizures
- serotonin syndrome
- urticaria
- vomiting
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- asthma
- breast-feeding
- bronchitis
- children
- emphysema
- fever
- geriatric
- headache
- heart failure
- hepatic disease
- infants
- MAOI therapy
- pregnancy
- tobacco smoking
- vomiting
Interactions
- Abiraterone
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Codeine
- Alfentanil
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amiodarone
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Ammonium Chloride
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Anticholinergics
- Artemether; Lumefantrine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Carisoprodol; Codeine
- Atazanavir; Cobicistat
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine; Fluticasone
- Azilsartan
- Azilsartan; Chlorthalidone
- Beclomethasone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benztropine
- Betamethasone
- Budesonide
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Candesartan
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Celecoxib
- Chlordiazepoxide; Clidinium
- Chlorpheniramine; Codeine
- Ciclesonide
- Cinacalcet
- Citalopram
- Clobazam
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Corticosteroids
- Cortisone
- Cyclosporine
- Dacomitinib
- Darifenacin
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Deflazacort
- Delavirdine
- Desvenlafaxine
- Dexamethasone
- Diclofenac
- Diclofenac; Misoprostol
- Dicyclomine
- Diflunisal
- Digoxin
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Donepezil; Memantine
- Dronedarone
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Eplerenone
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Escitalopram
- Esomeprazole; Naproxen
- Etodolac
- Famotidine; Ibuprofen
- Fedratinib
- Fenoprofen
- Fentanyl
- Flavoxate
- Fludrocortisone
- Flunisolide
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurbiprofen
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- food
- Formoterol; Mometasone
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Givosiran
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- grapefruit juice
- Heparin
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Ibuprofen
- Hydrocortisone
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Imatinib
- Indacaterol; Glycopyrrolate
- Indomethacin
- Irbesartan
- Isocarboxazid
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lasmiditan
- Levomilnacipran
- Linezolid
- Lisinopril
- Loperamide
- Loperamide; Simethicone
- Lorcaserin
- Losartan
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Memantine
- Mepenzolate
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methscopolamine
- Methylene Blue
- Methylprednisolone
- Milnacipran
- Mirabegron
- Mirtazapine
- Moexipril
- Mometasone
- Monoamine oxidase inhibitors
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nebivolol; Valsartan
- Nefazodone
- Nonsteroidal antiinflammatory drugs
- Olmesartan
- Oritavancin
- Oxaprozin
- Oxybutynin
- Ozanimod
- Panobinostat
- Paroxetine
- Pazopanib
- Peginterferon Alfa-2b
- Penicillin G
- Perindopril
- Perindopril; Amlodipine
- Phenelzine
- Piroxicam
- Prednisolone
- Prednisone
- Procarbazine
- Propafenone
- Propantheline
- Quinapril
- Quinine
- Ramipril
- Rasagiline
- Rofecoxib
- Rolapitant
- Sacubitril; Valsartan
- Safinamide
- Scopolamine
- Selegiline
- Serotonin-Receptor Agonists
- Sertraline
- Sibutramine
- Sodium Polystyrene Sulfonate
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulindac
- Tacrolimus
- Tedizolid
- Telmisartan
- Terbinafine
- Tocilizumab
- Tolmetin
- Trandolapril
- Trandolapril; Verapamil
- Tranylcypromine
- Triamcinolone
- Triamterene
- Tricyclic antidepressants
- Trihexyphenidyl
- Trimethoprim
- Valdecoxib
- Valsartan
- Vemurafenib
- Venlafaxine
- Vilazodone
- Vortioxetine
