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Dexamethasone Tobramycin Brand Names- Tobradex | Tobradex ST
What is Dexamethasone Tobramycin
Dexamethasone Tobramycin (Tobradex) is an ophthalmic preparation that combines dexamethasone (a corticosteroid) with tobramycin (an aminoglycoside antibiotic).
The combination is used to treat corticosteroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial infection exists.
TobraDex ST (tobramycin 0.3%/dexamethasone 0.05%) utilizes a novel suspension technology as compared to TobraDex (tobramycin 0.3%/dexamethasone 0.1%). Tobradex (tobramycin 0.3%/dexamethasone 0.1%) was approved by the FDA in August 1988. Tobradex ST (tobramycin 0.3%/dexamethasone 0.05%) was approved by the FDA in February 2009.
Indications
- Acinetobacter calcoaceticus
- bacterial conjunctivitis
- corneal abrasion
- Escherichia coli
- Haemophilus aegyptius
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Klebsiella aerogenes
- Klebsiella pneumoniae
- Moraxella lacunata
- Morganella morganii
- ophthalmic infection
- Proteus mirabilis
- Proteus vulgaris
- Pseudomonas aeruginosa
- Staphylococcus aureus (MRSA)
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- uveitis
Side Effects
- anaphylactoid reactions
- blepharitis
- bullous rash
- cataracts
- conjunctival hyperemia
- erythema
- erythema multiforme
- headache
- hypertension
- impaired wound healing
- infection
- keratitis
- ocular hypertension
- ocular infection
- ocular pain
- ocular pruritus
- optic neuritis
- pruritus
- rash
- superinfection
- urticaria
Monitoring Parameters
- intraocular pressure
Contraindications
- aminoglycoside hypersensitivity
- breast-feeding
- contact lenses
- corticosteroid hypersensitivity
- diabetes mellitus
- fungal infection
- increased intraocular pressure
- mycobacterial infection
- myopia
- ocular infection
- open-angle glaucoma
- pregnancy
- varicella
- viral infection
Interactions
There are no drug interactions associated with Dexamethasone; Tobramycin products.
