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Desloratadine Brand Names- Clarinex | Clarinex RediTab
What is Desloratadine
Desloratadine is a non-sedating, potent, second-generation long-acting antihistamine(H1-blocker).
Desloratadine is the active metabolite of loratadine, with a relative potency of 10 to 20 times that of loratadine in vitro. Both loratadine and desloratadine are non-sedating; however, desloratadine does not cause QT prolongation, even when given in doses 4 to 9 times the recommended dose in adults.
Desloratadine is utilized in adults and adolescents to relieve symptoms associated with seasonal allergic rhinitis, perennial allergic rhinitis, and chronic idiopathic urticaria.
Desloratadine was originally FDA approved in December 2001.
Indications
- allergic rhinitis
- chronic idiopathic urticaria
- perennial allergies
- pruritus
- seasonal allergies
For the management of symptoms of seasonal allergies or perennial allergies, including allergic rhinitis
Side Effects
- anaphylactoid reactions
- anorexia
- appetite stimulation
- cough
- diarrhea
- dizziness
- drowsiness
- dysmenorrhea
- dyspepsia
- dyspnea
- dystonic reaction
- edema
- elevated hepatic enzymes
- emotional lability
- epistaxis
- erythema
- fatigue
- fever
- headache
- hepatitis
- hyperactivity
- hyperbilirubinemia
- infection
- insomnia
- involuntary movements
- irritability
- maculopapular rash
- myalgia
- nausea
- palpitations
- pharyngitis
- pruritus
- rash
- restlessness
- rhinorrhea
- seizures
- sinus tachycardia
- urticaria
- vomiting
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- asthma
- breast-feeding
- driving or operating machinery
- geriatric
- hepatic disease
- infants
- neonates
- phenylketonuria
- pregnancy
- renal failure
- renal impairment
Interactions
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Diphenhydramine
- Acrivastine; Pseudoephedrine
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pyrilamine
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlorcyclizine
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Clemastine
- Cyclizine
- Cyproheptadine
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Doxylamine
- Doxylamine; Pyridoxine
- Fexofenadine
- Fexofenadine; Pseudoephedrine
- Heparin
- Hydroxyzine
- Levocetirizine
- Loratadine
- Loratadine; Pseudoephedrine
- Meclizine
- Sedating H1-blockers
- Sincalide
- Triprolidine
