Daunorubicin Brand Name– Cerubidine
What is Daunorubicin
Daunorubicin is an anthracycline chemotherapy agent indicated in combination with other anticancer agents for remission induction in acute nonlymphocytic leukemias (e.g., myelogenous, monocytic, and erythroid) in adults and for remission induction in acute lymphocytic leukemia in pediatric and adult patients. Dose-limiting cardiotoxicity and myelosuppression have been reported with daunorubicin therapy.
Indications
- acute lymphocytic leukemia (ALL)
- acute myelogenous leukemia (AML)
For the treatment of acute nonlymphocytic leukemia including acute myelogenous leukemia (AML)
as remission induction therapy of acute nonlymphocytic leukemia, in combination with other anticancer agents
Side Effects
- abdominal pain
- alopecia
- anaphylactoid reactions
- anemia
- AV block
- bleeding
- bone marrow suppression
- bundle-branch block
- cardiomyopathy
- cardiotoxicity
- chills
- contact dermatitis
- diarrhea
- fever
- heart failure
- hyperuricemia
- infection
- injection site reaction
- leukopenia
- myocarditis
- nail discoloration
- nausea
- neutropenia
- new primary malignancy
- oral ulceration
- pancytopenia
- pericarditis
- phlebitis
- premature ventricular contractions (PVCs)
- QT prolongation
- rash
- sinus tachycardia
- ST-T wave changes
- superinfection
- supraventricular tachycardia (SVT)
- thrombocytopenia
- tissue necrosis
- tumor lysis syndrome (TLS)
- urine discoloration
- urticaria
- ventricular tachycardia
- vomiting
Monitoring Parameters
- CBC with differential
- echocardiogram
- LFTs
- multi-gated radionuclide angiography (MUGA)
- serum bilirubin (total and direct)
- serum creatinine
- serum uric acid
Contraindications
- anthracycline hypersensitivity
- bone marrow suppression
- breast-feeding
- cardiac disease
- cardiotoxicity
- children
- dental disease
- dental work
- extravasation
- females
- hepatic disease
- herpes infection
- hyperkalemia
- hyperphosphatemia
- hyperuricemia
- hypocalcemia
- infants
- infection
- infertility
- intramuscular administration
- intramuscular injections
- jaundice
- maximum cumulative lifetime dose
- neutropenia
- pregnancy
- radiation therapy
- renal failure
- renal impairment
- requires a specialized care setting
- requires an experienced clinician
- subcutaneous administration
- thrombocytopenia
- tumor lysis syndrome (TLS)
- varicella
- viral infection
Interactions
- Bacillus Calmette-Guerin Vaccine, BCG
- Cyclophosphamide
- Cyclosporine
- Daclizumab
- Elbasvir; Grazoprevir
- Gadobenate Dimeglumine
- Influenza Virus Vaccine
- Intranasal Influenza Vaccine
- Live Vaccines
- Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
- Measles/Mumps/Rubella Vaccines, MMR
- Mycophenolate
- Palifermin
- Penicillamine
- Rotavirus Vaccine
- Rubella Virus Vaccine Live
- Sirolimus
- Smallpox and Monkeypox Vaccine, Live, Nonreplicating
- Smallpox Vaccine, Vaccinia Vaccine
- Trastuzumab
- Trastuzumab; Hyaluronidase
- Tuberculin Purified Protein Derivative, PPD
- Typhoid Vaccine
- Varicella-Zoster Virus Vaccine, Live
- Yellow Fever Vaccine, Live