Daunorubicin

Daunorubicin Brand Name– Cerubidine

What is Daunorubicin

Daunorubicin is an anthracycline chemotherapy agent indicated in combination with other anticancer agents for remission induction in acute nonlymphocytic leukemias (e.g., myelogenous, monocytic, and erythroid) in adults and for remission induction in acute lymphocytic leukemia in pediatric and adult patients. Dose-limiting cardiotoxicity and myelosuppression have been reported with daunorubicin therapy.

Indications

  1. acute lymphocytic leukemia (ALL)
  2. acute myelogenous leukemia (AML)

For the treatment of acute nonlymphocytic leukemia including acute myelogenous leukemia (AML)

as remission induction therapy of acute nonlymphocytic leukemia, in combination with other anticancer agents

Side Effects

  1. abdominal pain
  2. alopecia
  3. anaphylactoid reactions
  4. anemia
  5. AV block
  6. bleeding
  7. bone marrow suppression
  8. bundle-branch block
  9. cardiomyopathy
  10. cardiotoxicity
  11. chills
  12. contact dermatitis
  13. diarrhea
  14. fever
  15. heart failure
  16. hyperuricemia
  17. infection
  18. injection site reaction
  19. leukopenia
  20. myocarditis
  21. nail discoloration
  22. nausea
  23. neutropenia
  24. new primary malignancy
  25. oral ulceration
  26. pancytopenia
  27. pericarditis
  28. phlebitis
  29. premature ventricular contractions (PVCs)
  30. QT prolongation
  31. rash
  32. sinus tachycardia
  33. ST-T wave changes
  34. superinfection
  35. supraventricular tachycardia (SVT)
  36. thrombocytopenia
  37. tissue necrosis
  38. tumor lysis syndrome (TLS)
  39. urine discoloration
  40. urticaria
  41. ventricular tachycardia
  42. vomiting

Monitoring Parameters

  • CBC with differential
  • echocardiogram
  • LFTs
  • multi-gated radionuclide angiography (MUGA)
  • serum bilirubin (total and direct)
  • serum creatinine
  • serum uric acid

Contraindications

  • anthracycline hypersensitivity
  • bone marrow suppression
  • breast-feeding
  • cardiac disease
  • cardiotoxicity
  • children
  • dental disease
  • dental work
  • extravasation
  • females
  • hepatic disease
  • herpes infection
  • hyperkalemia
  • hyperphosphatemia
  • hyperuricemia
  • hypocalcemia
  • infants
  • infection
  • infertility
  • intramuscular administration
  • intramuscular injections
  • jaundice
  • maximum cumulative lifetime dose
  • neutropenia
  • pregnancy
  • radiation therapy
  • renal failure
  • renal impairment
  • requires a specialized care setting
  • requires an experienced clinician
  • subcutaneous administration
  • thrombocytopenia
  • tumor lysis syndrome (TLS)
  • varicella
  • viral infection

Interactions

  • Bacillus Calmette-Guerin Vaccine, BCG
  • Cyclophosphamide
  • Cyclosporine
  • Daclizumab
  • Elbasvir; Grazoprevir
  • Gadobenate Dimeglumine
  • Influenza Virus Vaccine
  • Intranasal Influenza Vaccine
  • Live Vaccines
  • Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
  • Measles/Mumps/Rubella Vaccines, MMR
  • Mycophenolate
  • Palifermin
  • Penicillamine
  • Rotavirus Vaccine
  • Rubella Virus Vaccine Live
  • Sirolimus
  • Smallpox and Monkeypox Vaccine, Live, Nonreplicating
  • Smallpox Vaccine, Vaccinia Vaccine
  • Trastuzumab
  • Trastuzumab; Hyaluronidase
  • Tuberculin Purified Protein Derivative, PPD
  • Typhoid Vaccine
  • Varicella-Zoster Virus Vaccine, Live
  • Yellow Fever Vaccine, Live
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