Cytomegalovirus Immune Globulin CMV-IGIV Brand Name– CytoGam
What is Cytomegalovirus Immune Globulin CMV-IGIV
Cytomegalovirus immune globulin (CMV-IGIV) is a parenteral, intravenously administered globulin fraction of human plasma, primarily immunoglobulin G.
CMV-IGIV is obtained, purified and standardized from human plasma. Cytomegalovirus immune globulin is used to attenuate primary CMV disease associated with renal transplantation.
Specifically, CMV-IGIV is given to CMV-seronegative patients receiving a kidney from a CMV-seropositive donor.
When used prophylactically in renal allograft recipients, CMV-IGIV has been shown to reduce the incidence of virologically confirmed CMV-associated syndromes, including episodes of CMV pneumonitis. Leukopenia was reduced, and there were no reports of fungal or parasitic superinfections in the CMV-IGIV recipients.
Indications
- cytomegalovirus (CMV) disease prophylaxis
- cytomegalovirus (CMV) pneumonitis
For primary cytomegalovirus (CMV) disease prophylaxis after organ transplantation, including kidney, lung, liver, pancreas, and heart transplantation
NOTE: Cytomegalovirus immune globulin has been designated an orphan drug by the FDA for this indication.
In CMV seronegative recipients of a renal allograft from a CMV seropositive donor
Side Effects
- abdominal pain
- acute respiratory distress syndrome (ARDS)
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- anuria
- apnea
- arthralgia
- aseptic meningitis
- azotemia
- back pain
- bronchospasm
- bullous rash
- cardiac arrest
- chest pain (unspecified)
- chills
- coma
- cyanosis
- drowsiness
- erythema multiforme
- fever
- flushing
- headache
- hemolysis
- hemolytic anemia
- hypotension
- hypoxia
- leukopenia
- muscle cramps
- myocardial infarction
- nausea
- oliguria
- osmotic nephrosis
- pallor
- pancytopenia
- paresis
- phlebitis
- photophobia
- pulmonary edema
- pulmonary embolism
- renal failure (unspecified)
- renal tubular necrosis
- retinal thrombosis
- seizures
- Stevens-Johnson syndrome
- stroke
- thromboembolism
- thrombosis
- tremor
- vomiting
- wheezing
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- agammaglobulinemia
- breast-feeding
- hypogammaglobulinemia
- IgA deficiency
- pregnancy
- sucrose hypersensitivity
Interactions
- Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
- Measles/Mumps/Rubella Vaccines, MMR
- Rotavirus Vaccine
- Rubella Virus Vaccine Live
- Varicella-Zoster Virus Vaccine, Live
