Cortisone Brand Name– Cortone
What is Cortisone
Cortisone is an endogenous corticosteroid hormone secreted by the adrenal cortex.
Unlike most of the corticosteroids, cortisone exhibits significant mineralocorticoid as well as glucocorticoid properties and is used clinically as replacement therapy in patients with adrenocortical insufficiency.
Cortisone has about 80% of the anti-inflammatory and sodium-retaining potency of hydrocortisone.
Synthetic corticosteroids that have minimal mineralocorticoid activity are preferred over cortisone for anti-inflammatory or immunosuppressive uses.
Commercial cortisone products are available as the acetate ester. Cortisone was approved by the FDA in 1950.
Indications
- acute lymphocytic leukemia (ALL)
- Addison’s disease
- adrenocortical insufficiency
- adrenogenital syndrome
- allergic conjunctivitis
- allergic rhinitis
- anaphylactic shock
- anaphylaxis
- angioedema
- ankylosing spondylitis
- anterior segment inflammation
- asthma
- atopic dermatitis
- berylliosis
- bronchospasm prophylaxis
- bursitis
- chorioretinitis
- chronic lymphocytic leukemia (CLL)
- chronic obstructive pulmonary disease (COPD)
- Churg-Strauss syndrome
- congenital adrenal hyperplasia
- contact dermatitis
- corneal ulcer
- Crohn’s disease
- dermatitis herpetiformis
- dermatomyositis
- eczema
- endophthalmitis
- epicondylitis
- erythroblastopenia
- exfoliative dermatitis
- gouty arthritis
- Graves’ ophthalmopathy
- hemangioma
- hemolytic anemia
- herpes zoster ocular infection
- Hodgkin lymphoma
- hypercalcemia
- hypoplastic anemia
- immune thrombocytopenic purpura (ITP)
- iritis
- juvenile rheumatoid arthritis (JRA)/juvenile idiopathic arthritis (JIA)
- keratitis
- kidney transplant rejection
- kidney transplant rejection prophylaxis
- laryngotracheobronchitis (croup)
- Loeffler’s syndrome
- meningitis
- mixed connective tissue disease
- multiple myeloma
- multiple sclerosis
- myasthenia gravis
- mycosis fungoides
- nasal polyps
- nephrotic syndrome
- non-Hodgkin’s lymphoma (NHL)
- optic neuritis
- osteoarthritis
- pemphigus
- perennial allergies
- pneumonitis
- polyarteritis nodosa
- polychondritis
- polymyositis
- postoperative ocular inflammation
- proteinuria
- pseudogout
- psoriasis
- psoriatic arthritis
- pulmonary edema
- rheumatic carditis
- rheumatoid arthritis
- sarcoidosis
- seasonal allergies
- seborrheic dermatitis
- serum sickness
- Stevens-Johnson syndrome
- systemic lupus erythematosus (SLE)
- temporal arteritis
- tenosynovitis
- thrombocytopenia
- thyroiditis
- trichinosis
- tuberculosis infection
- ulcerative colitis
- uveitis
- vernal keratoconjunctivitis
- Wegener’s granulomatosis
Side Effects
- abdominal pain
- acne vulgaris
- acneiform rash
- adrenocortical insufficiency
- alopecia
- amenorrhea
- amnesia
- anaphylactoid reactions
- anemia
- angina
- angioedema
- anorexia
- anxiety
- appetite stimulation
- arrhythmia exacerbation
- arthralgia
- avascular necrosis
- blurred vision
- bone fractures
- bradycardia
- candidiasis
- cardiac arrest
- cardiomyopathy
- cataracts
- constipation
- Cushing’s syndrome
- delirium
- depression
- diabetes mellitus
- diaphoresis
- diarrhea
- dizziness
- dysmenorrhea
- ecchymosis
- edema
- EEG changes
- elevated hepatic enzymes
- emotional lability
- erythema
- esophageal ulceration
- euphoria
- exfoliative dermatitis
- exophthalmos
- fever
- fluid retention
- gastritis
- GI bleeding
- GI perforation
- glossitis
- glycosuria
- growth inhibition
- hallucinations
- headache
- heart failure
- hepatomegaly
- hiccups
- hirsutism
- hypercholesterolemia
- hyperglycemia
- hypernatremia
- hypertension
- hyperthyroidism
- hypocalcemia
- hypokalemia
- hypotension
- hypothalamic-pituitary-adrenal (HPA) suppression
- hypothyroidism
- immunosuppression
- impaired cognition
- impaired wound healing
- increased intracranial pressure
- infection
- insomnia
- irritability
- lethargy
- lupus-like symptoms
- malaise
- mania
- memory impairment
- menstrual irregularity
- metabolic alkalosis
- myalgia
- myocardial infarction
- myopathy
- nausea
- neuritis
- neutropenia
- ocular hypertension
- ocular infection
- optic neuritis
- osteopenia
- osteoporosis
- palpitations
- pancreatitis
- papilledema
- paresthesias
- peptic ulcer
- perineal pain
- peripheral neuropathy
- petechiae
- phlebitis
- physiological dependence
- postmenopausal bleeding
- pruritus
- pseudotumor cerebri
- psychosis
- pulmonary edema
- purpura
- rash
- restlessness
- retinopathy
- seizures
- sinus tachycardia
- skin atrophy
- sodium retention
- striae
- stroke
- syncope
- telangiectasia
- tendon rupture
- thromboembolism
- thrombosis
- urticaria
- vasculitis
- vertigo
- visual impairment
- vomiting
- weakness
- weight gain
- weight loss
- withdrawal
- xerosis
Monitoring Parameters
- blood glucose
- blood pressure
- growth rate
- heart rate
- serum potassium
- weight
Contraindications
- abrupt discontinuation
- breast-feeding
- cataracts
- children
- coagulopathy
- corticosteroid hypersensitivity
- Cushing’s syndrome
- diabetes mellitus
- diverticulitis
- fungal infection
- geriatric
- GI disease
- glaucoma
- growth inhibition
- heart failure
- hepatic disease
- herpes infection
- hypertension
- hypothyroidism
- increased intracranial pressure
- infants
- infection
- inflammatory bowel disease
- measles
- myasthenia gravis
- myocardial infarction
- neonates
- ocular infection
- osteoporosis
- peptic ulcer disease
- pregnancy
- psychosis
- renal disease
- seizure disorder
- surgery
- thromboembolic disease
- tuberculosis
- ulcerative colitis
- vaccination
- varicella
- viral infection
- visual disturbance
Interactions
- Abatacept
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetazolamide
- Acetohexamide
- Adalimumab
- Albiglutide
- Aldesleukin, IL-2
- Alemtuzumab
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alogliptin; Metformin
- Alpha-glucosidase Inhibitors
- Altretamine
- Ambenonium Chloride
- Amifampridine
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminolevulinic Acid
- Aminosalicylate sodium, Aminosalicylic acid
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Antithymocyte Globulin
- Antitumor antibiotics
- Argatroban
- Arsenic Trioxide
- Asparaginase Erwinia chrysanthemi
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atenolol; Chlorthalidone
- Atracurium
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Azathioprine
- Azilsartan; Chlorthalidone
- Basiliximab
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bepridil
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bivalirudin
- Bortezomib
- Brompheniramine; Carbetapentane; Phenylephrine
- Bupropion
- Bupropion; Naltrexone
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Canagliflozin
- Canagliflozin; Metformin
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril; Hydrochlorothiazide, HCTZ
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Phenylephrine
- Carmustine, BCNU
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlorambucil
- Chlorothiazide
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Phenylephrine
- Chlorpropamide
- Chlorthalidone
- Chlorthalidone; Clonidine
- Choline Salicylate; Magnesium Salicylate
- Cimetidine
- Cisatracurium
- Citalopram
- Clindamycin
- Clofarabine
- Codeine; Phenylephrine; Promethazine
- Conivaptan
- Cosyntropin
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Denileukin Diftitox
- Denosumab
- Desmopressin
- Dextran
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Digoxin
- Dipeptidyl Peptidase-4 Inhibitors
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Dofetilide
- Doxacurium
- Droperidol
- Dulaglutide
- Echinacea
- Econazole
- Efalizumab
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril; Hydrochlorothiazide, HCTZ
- Ephedrine
- Eprosartan; Hydrochlorothiazide, HCTZ
- Erlotinib
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Estramustine
- Estrogens
- Exenatide
- Fluconazole
- Fluoxymesterone
- Fosinopril; Hydrochlorothiazide, HCTZ
- Gallium Ga 68 Dotatate
- Gemcitabine
- Gentamicin
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Glycerol Phenylbutyrate
- Guaifenesin; Phenylephrine
- Halofantrine
- Haloperidol
- Hemin
- Heparin
- Hetastarch
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Phenylephrine
- Hydroxyurea
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibritumomab Tiuxetan
- Incretin Mimetics
- Indapamide
- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
- Insulins
- Interferon Alfa-2a
- Interferon Alfa-2b
- Interferon Alfa-2b; Ribavirin
- Iohexol
- Isoproterenol
- Isotretinoin
- L-Asparaginase Escherichia coli
- Levetiracetam
- Levomethadyl
- Linagliptin; Metformin
- Liraglutide
- Live Vaccines
- Lixisenatide
- Lomustine, CCNU
- Loop diuretics
- Macimorelin
- Magnesium Salicylate
- Mannitol
- Mecasermin rinfabate
- Mecasermin, Recombinant, rh-IGF-1
- Meglitinides
- Melphalan
- Mepenzolate
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methacholine
- Methazolamide
- Methenamine; Sodium Acid Phosphate
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methoxsalen
- Methyclothiazide
- Metolazone
- Metyrapone
- Micafungin
- Mifepristone
- Mitoxantrone
- Mivacurium
- Moxifloxacin
- Muromonab-CD3
- Natalizumab
- Nateglinide
- Nelarabine
- Neostigmine
- Neuromuscular blockers
- Nicardipine
- Nonsteroidal antiinflammatory drugs
- Ocrelizumab
- Ondansetron
- Oxymetholone
- Pancuronium
- Pegaspargase
- Penicillamine
- Phenylephrine
- Phenylephrine; Promethazine
- Photosensitizing agents (topical)
- Physostigmine
- Pimozide
- Potassium
- Potassium Chloride
- Potassium Phosphate; Sodium Phosphate
- Potassium-sparing diuretics
- Pramlintide
- Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
- Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
- Propranolol
- Purine analogs
- Pyridostigmine
- Quetiapine
- Rapacuronium
- Regular Insulin
- Repaglinide
- Ritodrine
- Rituximab
- Rituximab; Hyaluronidase
- Rocuronium
- Salicylates
- Salsalate
- Sargramostim, GM-CSF
- Semaglutide
- SGLT2 Inhibitors
- Siponimod
- Sodium Benzoate; Sodium Phenylacetate
- Sodium Chloride
- Sodium Phenylbutyrate
- Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
- Somatropin, rh-GH
- Succinylcholine
- Sulfonylureas
- Telbivudine
- Tesamorelin
- Testosterone
- Thiazide diuretics
- Thiazolidinediones
- Thyroid hormones
- Tobramycin
- Tolazamide
- Tolbutamide
- Tositumomab
- Tranexamic Acid
- Trastuzumab; Hyaluronidase
- Tretinoin, ATRA
- Tuberculin Purified Protein Derivative, PPD
- Tubocurarine
- Vancomycin
- Vecuronium
- Vigabatrin
- Vinblastine
- Vincristine Liposomal
- Vorinostat
- Warfarin
- Zafirlukast
- Zileuton