Cisplatin

Cisplatin Brand Name– Platinol | Platinol -AQ

What is Cisplatin

Cisplatin is a non-cell-cycle specific alkylating agent with activity in many different solid tumors and lymphoma.

It is indicated for the treatment of advanced testicular cancer, advanced ovarian cancer, and advanced bladder cancer, but also has several off-label uses including head and neck cancer, non-Hodgkin’s Lymphoma (NHL), small cell (SCLC) and non-small cell lung cancer (NSCLC), and many more.

Cisplatin can cause severe nephrotoxicity including acute renal failure that becomes more prolonged and severe with repeated courses of treatment.

Ensure adequate hydration before, during, and after administration; closely monitor renal function and serum electrolytes.

Indications

1. anal cancer
2. biliary tract cancer
3. bladder cancer
4. endometrial cancer
5. gastric cancer
6. head and neck cancer
7. hepatocellular cancer
8. malignant melanoma
9. mesothelioma
10. neuroblastoma
11. non-Hodgkin’s lymphoma (NHL)
12. non-small cell lung cancer (NSCLC)
13. ovarian cancer
14. penile cancer
15. peripheral T-cell lymphoma (PTCL)
16. small cell lung cancer (SCLC)
17. testicular cancer
18. thymic carcinoma
19. thymoma
20. trophoblastic disease

Side Effects

1. alopecia
2. anorexia
3. asthenia
4. azotemia
5. blurred vision
6. bone marrow suppression
7. cholestasis
8. dehydration
9. diarrhea
10. dysgeusia
11. edema
12. elevated hepatic enzymes
13. encephalopathy
14. erythema
15. Fanconi syndrome
16. fever
17. GI perforation
18. hearing loss
19. heart failure
20. hemolytic anemia
21. hemolytic-uremic syndrome
22. hepatic failure
23. hiccups
24. hyperamylasemia
25. hyperbilirubinemia
26. hyperuricemia
27. hypocalcemia
28. hypokalemia
29. hypomagnesemia
30. hyponatremia
31. hypophosphatemia
32. hypotension
33. infection
34. injection site reaction
35. interstitial lung disease
36. leukoencephalopathy
37. leukopenia
38. malaise
39. muscle cramps
40. myocardial infarction
41. nausea
42. nephrotoxicity
43. neutropenia
44. new primary malignancy
45. optic neuritis
46. ototoxicity
47. pancreatitis
48. papilledema
49. paresthesias
50. pericardial effusion
51. peripheral neuropathy
52. pneumonitis
53. progressive multifocal leukoencephalopathy
54. pulmonary embolism
55. rash
56. renal failure (unspecified)
57. renal tubular acidosis (RTA)
58. retinal pigment changes
59. seizures
60. serious hypersensitivity reactions or anaphylaxis
61. SIADH
62. sinus tachycardia
63. steatosis
64. stomatitis
65. stroke
66. tetany
67. thrombocytopenia
68. thromboembolism
69. thrombotic microangiopathy
70. tinnitus
71. tissue necrosis
72. tremor
73. tumor lysis syndrome (TLS)
74. visual impairment
75. vomiting
76. weakness
77. wheezing

Monitoring Parameters

• audiometry
• CBC with differential
• neurologic function
• pregnancy testing
• serum creatinine/BUN
• serum electrolytes
• serum magnesium

Contraindications

• bone marrow suppression
• breast-feeding
• chemotherapy-induced nausea/vomiting
• children
• contraception requirements
• dehydration
• extravasation
• fungal infection
• geriatric
• hearing impairment
• herpes infection
• infants
• infection
• infertility
• intramuscular administration
• male-mediated teratogenicity
• neonates
• nephrotoxicity
• ototoxicity
• peripheral neuropathy
• platinum compound hypersensitivity
• pregnancy
• pregnancy testing
• renal disease
• renal failure
• renal impairment
• reproductive risk
• serious hypersensitivity reactions or anaphylaxis
• subcutaneous administration
• varicella
• viral infection

Interactions

• Acyclovir
• Adefovir
• Amikacin
• Aminoglycosides
• Amphotericin B
• Amphotericin B cholesteryl sulfate complex (ABCD)
• Amphotericin B lipid complex (ABLC)
• Amphotericin B liposomal (LAmB)
• Aprotinin
• Arsenic Trioxide
• Bacitracin
• Bictegravir; Emtricitabine; Tenofovir Alafenamide
• Bleomycin
• Bumetanide
• Capreomycin
• Carbamazepine
• Cetuximab
• Cidofovir
• Cisapride
• Clozapine
• Colistimethate, Colistin, Polymyxin E
• Cyclosporine
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Desmopressin
• Doravirine; Lamivudine; Tenofovir disoproxil fumarate
• Droperidol
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Emtricitabine; Rilpivirine; Tenofovir alafenamide
• Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
• Emtricitabine; Tenofovir alafenamide
• Emtricitabine; Tenofovir disoproxil fumarate
• Entecavir
• Ethacrynic Acid
• Foscarnet
• Fosphenytoin
• Furosemide
• Gadobenate Dimeglumine
• Gallium
• Gallium Ga 68 Dotatate
• Ganciclovir
• Gentamicin
• Hyaluronidase, Recombinant; Immune Globulin
• Ifosfamide
• Immune Globulin IV, IVIG, IGIV
• Inotersen
• Kanamycin
• Lamivudine; Tenofovir Disoproxil Fumarate
• Lithium
• Live Vaccines
• Mannitol
• Methotrexate
• Neomycin
• Non-Ionic Contrast Media
• Palifermin
• Paromomycin
• Penicillamine
• Pentamidine
• Phenytoin
• Plazomicin
• Polymyxin B
• Polymyxins
• Rituximab
• Rituximab; Hyaluronidase
• Streptomycin
• Streptozocin
• Tacrolimus
• Telavancin
• Telbivudine
• Tenofovir Alafenamide
• Tenofovir Alafenamide
• Tenofovir, PMPA
• Thalidomide
• Tobramycin
• Torsemide
• Trandolapril; Verapamil
• Tuberculin Purified Protein Derivative, PPD
• Valacyclovir
• Valganciclovir
• Vancomycin
• Verapamil