Cerivastatin

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Cerivastatin Brand Name– Baycol

What is Cerivastatin

Cerivastatin is a highly potent, competitive HMG-CoA reductase inhibitor, which is no longer marketed in the US due to safety concerns.

Cerivastatin was indicated for the treatment of primary hypercholesterolemia and mixed dyslipidemia (Fredrickson types IIa and IIb). Cerivastatin potently lowers LDL cholesterol and triglycerides; it reduces LDL cholesterol by up to 42% at the 0.8 mg once daily dose.

Cerivastatin was approved for the treatment of hypercholesterolemia June 27, 1997. In the US, it is assigned the trade name Baycol; in the UK, it is called Lipobay.

Baycol was voluntarily withdrawn from the US market on August 8, 2001, due to 31 cases of fatal rhabdomyolysis, reported more frequently than with other statins; 12 of these cases involved concomitant gemfibrozil use.

Lipobay was subsequently withdrawn from international markets except for Japan where gemfibrozil is unavailable.

Indications

  1. hypercholesterolemia
  2. hyperlipoproteinemia
  3. hypertriglyceridemia

For the treatment of hypercholesterolemia, hyperlipoproteinemia, and/or hypertriglyceridemia† (to reduce elevated total cholesterol, LDL-cholesterol, apolipoprotein B, and triglyceride levels; and raise HDL-cholesterol) in patients with primary hypercholesterolemia and mixed dyslipidemia (Fredrickson Types IIa and IIb) when the response to dietary restriction has been inadequate

Side Effects

  1. abdominal pain
  2. angioedema
  3. arthralgia
  4. back pain
  5. blurred vision
  6. cholestasis
  7. cirrhosis
  8. constipation
  9. diabetes mellitus
  10. diarrhea
  11. dizziness
  12. dysarthria
  13. dyspepsia
  14. dysphagia
  15. elevated hepatic enzymes
  16. fever
  17. flatulence
  18. headache
  19. hepatic failure
  20. hepatic necrosis
  21. hepatitis
  22. insomnia
  23. malaise
  24. muscle paralysis
  25. myalgia
  26. myasthenia
  27. myoglobinuria
  28. myopathy
  29. nausea
  30. pancreatitis
  31. peripheral edema
  32. peripheral neuropathy
  33. pharyngitis
  34. renal tubular obstruction
  35. rhabdomyolysis
  36. rhinitis
  37. sinusitis
  38. urticaria
  39. visual impairment
  40. vomiting
  41. weakness

Monitoring Parameters

  • (drug no longer available)
  • creatine phosphokinase (CPK)
  • LFTs
  • serum cholesterol profile

Contraindications

  • alcoholism
  • breast-feeding
  • children
  • cholestasis
  • contraception requirements
  • electrolyte imbalance
  • endocrine disease
  • females
  • geriatric
  • hepatic disease
  • hepatic encephalopathy
  • hepatitis
  • hypotension
  • hypothyroidism
  • infants
  • infection
  • jaundice
  • mannitol hypersensitivity
  • myopathy
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • rhabdomyolysis
  • seizure disorder
  • surgery
  • trauma

Cerivastatin is contraindicated in any patient with cerivastatin hypersensitivity or hypersensitive to any component of the medication.

Interactions

  • Amiodarone
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Atazanavir; Cobicistat
  • Carbamazepine
  • Clarithromycin
  • Clofarabine
  • Cobicistat
  • Conivaptan
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Itraconazole
  • Ketoconazole
  • Lovastatin; Niacin
  • Nefazodone
  • Niacin, Niacinamide
  • Niacin; Simvastatin
  • Omeprazole; Amoxicillin; Rifabutin
  • Oritavancin
  • Posaconazole
  • Rifabutin
  • Rifapentine
  • Simeprevir
  • Trandolapril; Verapamil
  • Verapamil
  • Voriconazole

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