Cerivastatin Brand Name– Baycol
What is Cerivastatin
Cerivastatin is a highly potent, competitive HMG-CoA reductase inhibitor, which is no longer marketed in the US due to safety concerns.
Cerivastatin was indicated for the treatment of primary hypercholesterolemia and mixed dyslipidemia (Fredrickson types IIa and IIb). Cerivastatin potently lowers LDL cholesterol and triglycerides; it reduces LDL cholesterol by up to 42% at the 0.8 mg once daily dose.
Cerivastatin was approved for the treatment of hypercholesterolemia June 27, 1997. In the US, it is assigned the trade name Baycol; in the UK, it is called Lipobay.
Baycol was voluntarily withdrawn from the US market on August 8, 2001, due to 31 cases of fatal rhabdomyolysis, reported more frequently than with other statins; 12 of these cases involved concomitant gemfibrozil use.
Lipobay was subsequently withdrawn from international markets except for Japan where gemfibrozil is unavailable.
Indications
- hypercholesterolemia
- hyperlipoproteinemia
- hypertriglyceridemia
For the treatment of hypercholesterolemia, hyperlipoproteinemia, and/or hypertriglyceridemia† (to reduce elevated total cholesterol, LDL-cholesterol, apolipoprotein B, and triglyceride levels; and raise HDL-cholesterol) in patients with primary hypercholesterolemia and mixed dyslipidemia (Fredrickson Types IIa and IIb) when the response to dietary restriction has been inadequate
Side Effects
- abdominal pain
- angioedema
- arthralgia
- back pain
- blurred vision
- cholestasis
- cirrhosis
- constipation
- diabetes mellitus
- diarrhea
- dizziness
- dysarthria
- dyspepsia
- dysphagia
- elevated hepatic enzymes
- fever
- flatulence
- headache
- hepatic failure
- hepatic necrosis
- hepatitis
- insomnia
- malaise
- muscle paralysis
- myalgia
- myasthenia
- myoglobinuria
- myopathy
- nausea
- pancreatitis
- peripheral edema
- peripheral neuropathy
- pharyngitis
- renal tubular obstruction
- rhabdomyolysis
- rhinitis
- sinusitis
- urticaria
- visual impairment
- vomiting
- weakness
Monitoring Parameters
- (drug no longer available)
- creatine phosphokinase (CPK)
- LFTs
- serum cholesterol profile
Contraindications
- alcoholism
- breast-feeding
- children
- cholestasis
- contraception requirements
- electrolyte imbalance
- endocrine disease
- females
- geriatric
- hepatic disease
- hepatic encephalopathy
- hepatitis
- hypotension
- hypothyroidism
- infants
- infection
- jaundice
- mannitol hypersensitivity
- myopathy
- pregnancy
- renal disease
- renal failure
- renal impairment
- rhabdomyolysis
- seizure disorder
- surgery
- trauma
Cerivastatin is contraindicated in any patient with cerivastatin hypersensitivity or hypersensitive to any component of the medication.
Interactions
- Amiodarone
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Atazanavir; Cobicistat
- Carbamazepine
- Clarithromycin
- Clofarabine
- Cobicistat
- Conivaptan
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Itraconazole
- Ketoconazole
- Lovastatin; Niacin
- Nefazodone
- Niacin, Niacinamide
- Niacin; Simvastatin
- Omeprazole; Amoxicillin; Rifabutin
- Oritavancin
- Posaconazole
- Rifabutin
- Rifapentine
- Simeprevir
- Trandolapril; Verapamil
- Verapamil
- Voriconazole
