Caspofungin

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Caspofungin Brand Name– Cancidas

What is Caspofungin

Caspofungin is an intravenous echinocandin antifungal agent that is used for the treatment of invasive aspergillosis that is refractory to or intolerant of other therapies, esophageal candidiasis, candidemia, and for empiric treatment of presumed fungal infections in febrile neutropenia.

Common adverse events reported with caspofungin include fever and infusion-related toxicity.

Caspofungin has shown activity against Candida species and in regions of active cell growth of the hyphae of Aspergillus fumigatus.

Caspofungin has been shown to be active both in vitro and in clinical infections against most strains of Aspergillus fumigatusAspergillus flavusAspergillus terreus, Candida albicansCandida glabrataCandida guilliermondiiCandida krusei, Candida parapsilosis, and Candida tropicalis. Caspofungin was FDA-approved in January 2001.

Indications

  1. aspergillosis
  2. aspergillosis prophylaxis
  3. Aspergillus flavus
  4. Aspergillus fumigatus
  5. Aspergillus niger
  6. Aspergillus sp.
  7. Aspergillus terreus
  8. bone and joint infections
  9. Candida albicans
  10. Candida glabrata
  11. Candida guilliermondii
  12. Candida krusei
  13. Candida lusitaniae
  14. Candida parapsilosis
  15. Candida sp.
  16. Candida tropicalis
  17. candidemia
  18. candidiasis
  19. candidiasis prophylaxis
  20. endocarditis
  21. esophageal candidiasis
  22. febrile neutropenia
  23. infectious arthritis
  24. intraabdominal abscess
  25. intraabdominal infections
  26. oropharyngeal candidiasis (thrush)
  27. osteomyelitis
  28. peritonitis
  29. Pneumocystis pneumonia (PCP)
  30. pneumonia

Side Effects

  1. abdominal pain
  2. anaphylactoid reactions
  3. anemia
  4. angioedema
  5. anorexia
  6. anxiety
  7. arrhythmia exacerbation
  8. arthralgia
  9. asthenia
  10. atrial fibrillation
  11. back pain
  12. bradycardia
  13. bronchospasm
  14. cardiac arrest
  15. chills
  16. coagulopathy
  17. confusion
  18. constipation
  19. cough
  20. depression
  21. diarrhea
  22. dizziness
  23. drowsiness
  24. dyspepsia
  25. dyspnea
  26. edema
  27. elevated hepatic enzymes
  28. epistaxis
  29. erythema
  30. erythema multiforme
  31. exfoliative dermatitis
  32. fatigue
  33. fever
  34. fluid retention
  35. flushing
  36. headache
  37. hematuria
  38. hepatic failure
  39. hepatic necrosis
  40. hepatitis
  41. hepatomegaly
  42. hyperbilirubinemia
  43. hypercalcemia
  44. hyperglycemia
  45. hypertension
  46. hypokalemia
  47. hypomagnesemia
  48. hypotension
  49. hypoxia
  50. infection
  51. injection site reaction
  52. insomnia
  53. jaundice
  54. myocardial infarction
  55. nausea
  56. neutropenia
  57. pancreatitis
  58. peripheral edema
  59. petechiae
  60. phlebitis
  61. pleural effusion
  62. pruritus
  63. pulmonary edema
  64. rash
  65. renal failure (unspecified)
  66. seizures
  67. sinus tachycardia
  68. skin ulcer
  69. Stevens-Johnson syndrome
  70. tachypnea
  71. thrombocytopenia
  72. toxic epidermal necrolysis
  73. tremor
  74. urticaria
  75. vomiting

Contraindications

  • breast-feeding
  • pregnancy

Caspofungin is contraindicated for use in patients with known hypersensitivity (e.g., anaphylaxis) to any of the product components.

Interactions

  • Carbamazepine
  • Cyclosporine
  • Dexamethasone
  • Dichlorphenamide
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Ethotoin
  • Fosphenytoin
  • Nevirapine
  • Phenytoin
  • Rifamycins
  • Sirolimus
  • Tacrolimus

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