Bempedoic Acid Ezetimibe Brand Name– NEXLIZET
What is Bempedoic Acid Ezetimibe
Bempedoic acid Ezetimibe is an oral antilipemic combination. Bempedoic acid is an adenosine triphosphate-citrate lyase (ACL) inhibitor.
Ezetimibe is a potent cholesterol absorption inhibitor and selectively blocks the intestinal absorption of cholesterol and related phytosterols.
This fixed-dose combination medication is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease in adults who require additional lowering of LDL-C.
Bempedoic acid is an inactive prodrug that requires coenzyme A (CoA) activation by very long-chain acyl-CoA synthetase 1 (ACSVL1).
Since ACSVL1 is primarily located in the liver and not in adipose tissue or muscle, it is theorized to have reduced adverse effects, such as myotoxicity, due to minimal exposure to non-hepatic tissues.
Indications
- atherosclerosis
- heterozygous familial hypercholesterolemia
Side Effects
- abdominal pain
- anaphylactoid reactions
- anemia
- angioedema
- arthralgia
- atrial fibrillation
- back pain
- cholecystitis
- cholelithiasis
- constipation
- cough
- depression
- diarrhea
- dizziness
- elevated hepatic enzymes
- erythema multiforme
- fatigue
- gout
- headache
- hepatitis
- hyperuricemia
- infection
- influenza
- leukopenia
- muscle cramps
- myalgia
- myopathy
- pancreatitis
- paresthesias
- pharyngitis
- prostatic hypertrophy
- rash
- rhabdomyolysis
- sinusitis
- tendon rupture
- thrombocytopenia
- thrombocytosis
- urticaria
Contraindications
- breast-feeding
- corticosteroid therapy
- gout
- hepatic disease
- hyperuricemia
- pregnancy
- renal failure
- tendon rupture
Interactions
- Antacids
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Pravastatin
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Cholestyramine
- Colesevelam
- Colestipol
- Cyclosporine
- Eltrombopag
- Ezetimibe; Simvastatin
- Fenofibrate
- Fenofibric Acid
- Gemfibrozil
- Niacin; Simvastatin
- Omeprazole; Sodium Bicarbonate
- Pravastatin
- Simvastatin
- Simvastatin; Sitagliptin
- Sodium Bicarbonate
- Warfarin
