Belinostat

Belinostat Brand Name– Beleodaq

What is Belinostat

Belinostat (PXD-101) is a class I/II intravenous histone deacetylase (HDAC) inhibitor.

HDAC plays an important role in the epigenetic silencing of tumor suppressor genes.

The overall response rate was 25% following a median of 2 cycles of belinostat in 24 patients with relapsed or refractory peripheral T-cell lymphoma (PTCL) in a multinational, 2-cohort, phase II trial.

In July 2014, belinostat (Beleodaq) was approved by the FDA for the treatment of relapsed or refractory PTCL.

It was an accelerated approval based on tumor response rate and duration of response; however, continued approval may be dependent upon verification and description of clinical benefit in confirmatory trials.

Indications

  • peripheral T-cell lymphoma (PTCL)

For the treatment of relapsed or refractory peripheral T-cell lymphoma (PTCL)

Side Effects

  1. abdominal pain
  2. anemia
  3. anorexia
  4. chills
  5. constipation
  6. cough
  7. diarrhea
  8. dizziness
  9. dyspnea
  10. elevated hepatic enzymes
  11. fatigue
  12. fever
  13. headache
  14. hepatic failure
  15. hypokalemia
  16. hypotension
  17. infection
  18. nausea
  19. neutropenia
  20. peripheral edema
  21. phlebitis
  22. pruritus
  23. QT prolongation
  24. rash
  25. renal failure (unspecified)
  26. thrombocytopenia
  27. tumor lysis syndrome (TLS)
  28. ventricular fibrillation
  29. vomiting

Monitoring Parameters

  • CBC with differential
  • LFTs
  • pregnancy testing
  • serum creatinine/BUN

Contraindications

  • anemia
  • Asian patients
  • Black patients
  • bone marrow suppression
  • breast-feeding
  • Caucasian patients
  • chemotherapy
  • contraception requirements
  • hepatic disease
  • infection
  • infertility
  • leukopenia
  • male-mediated teratogenicity
  • neutropenia
  • pregnancy
  • pregnancy testing
  • reproductive risk
  • sepsis
  • thrombocytopenia
  • tumor lysis syndrome (TLS)

Interactions

  • Atazanavir
  • Atazanavir; Cobicistat
  • Clozapine
  • Gemfibrozil
  • Palifermin
  • Penicillamine
  • Tuberculin Purified Protein Derivative, PPD
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