Belatacept Brand Name– NULOJIX
What is Belatacept
Belatacept is a selective T-cell costimulation blocker indicated for rejection prophylaxis in adults receiving a kidney transplant.
Belatacept is used in combination with basiliximab induction, mycophenolate mofetil, and corticosteroids and is only indicated for use in Epstein-Barr virus (EBV) seropositive patients.
Belatacept is contraindicated for use by patients who are EBV seronegative or with unknown serostatus because of the risk of post-transplant lymphoproliferative disorder.
Belatacept was FDA approved in June 2011.
Indications
- kidney transplant rejection prophylaxis
For kidney transplant rejection prophylaxis in combination with basiliximab induction, mycophenolate mofetil, and corticosteroids
Side Effects
- abdominal pain
- acne vulgaris
- alopecia
- anaphylactoid reactions
- anemia
- antibody formation
- anxiety
- arthralgia
- atrial fibrillation
- back pain
- BK virus-associated nephropathy
- constipation
- cough
- diabetes mellitus
- diarrhea
- dizziness
- dyspnea
- dysuria
- fever
- Guillain-Barre syndrome
- headache
- hematuria
- hypercholesterolemia
- hyperglycemia
- hyperhidrosis
- hyperkalemia
- hypertension
- hyperuricemia
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypophosphatemia
- hypotension
- immunosuppression
- infection
- influenza
- insomnia
- leukoencephalopathy
- leukopenia
- lymphocele
- musculoskeletal pain
- nausea
- neutropenia
- new primary malignancy
- peripheral edema
- pharyngitis
- post-transplant lymphoproliferative disorder (PTLD)
- proteinuria
- renal failure (unspecified)
- renal tubular necrosis
- stomatitis
- thrombosis
- tremor
- urinary incontinence
- vomiting
- wound dehiscence
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- breast-feeding
- children
- diabetes mellitus
- immunosuppression
- infants
- infection
- liver transplant
- mortality
- neonates
- new primary malignancy
- post-transplant lymphoproliferative disorder (PTLD)
- pregnancy
- progressive multifocal leukoencephalopathy
- requires a specialized care setting
- requires an experienced clinician
- sunlight (UV) exposure
- thromboembolic disease
- tuberculosis
- vaccination
Interactions
- Antithymocyte Globulin
- Bacillus Calmette-Guerin Vaccine, BCG
- Influenza Virus Vaccine
- Intranasal Influenza Vaccine
- Live Vaccines
- Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
- Measles/Mumps/Rubella Vaccines, MMR
- Rotavirus Vaccine
- Rubella Virus Vaccine Live
- Smallpox and Monkeypox Vaccine, Live, Nonreplicating
- Smallpox Vaccine, Vaccinia Vaccine
- Typhoid Vaccine
- Varicella-Zoster Virus Vaccine, Live
- Yellow Fever Vaccine, Live
