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Bacitracin Hydrocortisone Neomycin Polymyxin B Brand Names
AK-Spore HC Ophthalmic | Cortisporin | Cortomycin | Neo-Polycin HC | Neotricin HC | Ocu-Cort
What is Bacitracin Hydrocortisone Neomycin Polymyxin B
Bacitracin Hydrocortisone Neomycin Polymyxin B are used together in ophthalmic preparations or in a topical ointment to treat corticosteroid-responsive dermatoses with secondary infection.
Hydrocortisone is a corticosteroid that exhibits both mineralocorticoid and glucocorticoid activity; it is used in these preparations for its antiinflammatory properties.
Bacitracin is a mixture of cyclic polypeptides produced by Bacillus subtilis. Neomycin is a aminoglycoside antibiotic derived from cultures of Streptomyces fradiae.
Polymyxin B is a polypeptide antibiotic derived from a strain of Bacillus polymyxa.
Neomycin and polymyxin B affect primarily gram-negative, aerobic bacteria, while bacitracin is effective against gram-positive organisms. The FDA approved bacitracin, hydrocortisone, neomycin, and polymyxin B ophthalmic and topical preparations prior to 1982.
Indications
- bacterial conjunctivitis
- dermatitis
- Enterobacter sp.
- Escherichia coli
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Klebsiella sp.
- Neisseria sp.
- ophthalmic infection
- Pseudomonas aeruginosa
- Staphylococcus aureus (MSSA)
- Streptococcus pneumoniae
- Streptococcus sp.
- uveitis
Side Effects
- acneiform rash
- cataracts
- contact dermatitis
- erythema
- folliculitis
- hearing loss
- hypertrichosis
- impaired wound healing
- miliaria
- ocular hypertension
- ocular irritation
- ocular pruritus
- pruritus
- rash
- skin atrophy
- skin hypopigmentation
- skin irritation
- striae
- superinfection
- xerosis
Monitoring Parameters
- intraocular pressure
Contraindications
- aminoglycoside hypersensitivity
- breast-feeding
- cataracts
- children
- contact lenses
- corticosteroid hypersensitivity
- diarrhea
- fungal infection
- geriatric
- glaucoma
- hearing impairment
- herpes infection
- hypothalamic-pituitary-adrenal (HPA) suppression
- infants
- neomycin hypersensitivity
- neonates
- occlusive dressing
- ocular exposure
- ocular surgery
- polymyxin hypersensitivity
- pregnancy
- pseudomembranous colitis
- renal failure
- renal impairment
- tuberculosis
- tympanic membrane perforation
- varicella
- viral infection
Interactions
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Bumetanide
- Ethacrynic Acid
- Furosemide
- Loop diuretics
- Torsemide
