Azilsartan Chlorthalidone Brand Name– Edarbyclor
What is Azilsartan Chlorthalidone
Azilsartan chlorthalidone is an oral combination product for the treatment of hypertension.
Azilsartan is an angiotensin II receptor antagonist, also known as an angiotensin II receptor blocker (ARB) Chlorthalidone is a thiazide diuretic. The combination of an ARB with a low-dose, thiazide-type diuretic results in additive blood pressure reduction.
The likelihood of achieving target blood pressure goals (less than 140/90 mmHg) for a patient with a baseline blood pressure of 140/105 mmHg is 48% on azilsartan monotherapy, 51% systolic and 40% diastolic with chlorthalidone monotherapy, and 85% with the combination of azilsartan and chlorthalidone.
Azilsartan chlorthalidone was approved by the FDA in December 2011.
Indications
- hypertension
Side Effects
- angioedema
- asthenia
- azotemia
- cough
- diarrhea
- dizziness
- dyspepsia
- fatigue
- headache
- hypercholesterolemia
- hyperkalemia
- hyperuricemia
- hypokalemia
- hyponatremia
- hypotension
- muscle cramps
- nausea
- new primary malignancy
- oliguria
- orthostatic hypotension
- pruritus
- rash
- renal failure (unspecified)
- syncope
- teratogenesis
Monitoring Parameters
- blood pressure
- serum creatinine/BUN
- serum electrolytes
- serum uric acid
Contraindications
- anuria
- breast-feeding
- electrolyte imbalance
- geriatric
- gout
- heart failure
- hepatic disease
- hyperkalemia
- hyperuricemia
- hypochloremia
- hypokalemia
- hypomagnesemia
- hyponatremia
- hypovolemia
- infants
- metabolic alkalosis
- neonates
- pregnancy
- renal artery stenosis
- renal failure
- renal impairment
Interactions
- Acarbose
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Pseudoephedrine
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