Axitinib Brand Name– INLYTA
What is Axitinib
Axitinib is an oral agent that works by inhibiting receptor tyrosine kinases, including vascular endothelial growth factor receptors (VEGFR)-1, VEGFR-2, and VEGFR-3.
It is approved for the treatment of advanced renal cell carcinoma (RCC) after failure of one prior systemic therapy.
Progression-free survival was significantly improved with axitinib compared with sorafenib in a multicenter, randomized, phase 3 study in patients with progressive RCC after one first-line therapy including a sunitinib-, temsirolimus-, or cytokine-based regimen or bevacizumab plus interferon alfa.
Patients should not receive axitinib for at least 2 days before elective surgery due to wound healing complications that may be associated with treatment; do not administer axitinib for at least 2 weeks after major surgery and until adequate wound healing has occurred.
Indications
- renal cell cancer
For the treatment of renal cell cancer
for the first-line treatment of advanced renal cell cancer, in combination with pembrolizumab
Side Effects
- abdominal pain
- alopecia
- anemia
- anorexia
- arthralgia
- asthenia
- bleeding
- constipation
- cough
- dehydration
- diarrhea
- dizziness
- dysgeusia
- dyspepsia
- dysphonia
- dyspnea
- elevated hepatic enzymes
- epistaxis
- erythema
- fatigue
- gastrointestinal fistula
- GI bleeding
- GI perforation
- headache
- heart failure
- hematuria
- hemoptysis
- hemorrhoids
- hyperamylasemia
- hypercalcemia
- hyperglycemia
- hyperkalemia
- hypernatremia
- hypertension
- hypertensive crisis
- hyperthyroidism
- hypoalbuminemia
- hypocalcemia
- hypoglycemia
- hyponatremia
- hypophosphatemia
- hypothyroidism
- intracranial bleeding
- leukoencephalopathy
- leukopenia
- lymphopenia
- melena
- myalgia
- myocardial infarction
- nausea
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- polycythemia
- proteinuria
- pruritus
- pulmonary embolism
- rash
- retinal thrombosis
- stomatitis
- stroke
- thrombocytopenia
- thrombosis
- tinnitus
- vomiting
- weight loss
- xerosis
Monitoring Parameters
- blood pressure
- LFTs
- pregnancy testing
- thyroid function tests (TFTs)
- urinalysis
Contraindications
- bleeding
- breast-feeding
- cardiac disease
- children
- contraception requirements
- diabetes mellitus
- encephalopathy
- fistula
- GI bleeding
- GI perforation
- heart failure
- hepatic disease
- hepatotoxicity
- hyperlipidemia
- hypertension
- hyperthyroidism
- hypothyroidism
- impaired wound healing
- infants
- infertility
- myocardial infarction
- neonates
- pregnancy
- pregnancy testing
- proteinuria
- renal impairment
- reproductive risk
- surgery
- thromboembolic disease
- thyroid disease
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Aldesleukin, IL-2
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bexarotene
- Bosentan
- Butabarbital
- Carbamazepine
- Cenobamate
- Ceritinib
- Chloramphenicol
- Clarithromycin
- Cobicistat
- Cocaine
- Conivaptan
- Dabrafenib
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Dexamethasone
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enzalutamide
- Eslicarbazepine
- Etravirine
- Fosamprenavir
- Fosphenytoin
- grapefruit juice
- Idelalisib
- Indinavir
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Letermovir
- Lopinavir; Ritonavir
- Lorlatinib
- Lumacaftor; Ivacaftor
- Mephobarbital
- Methohexital
- Mifepristone
- Mitotane
- Modafinil
- Nafcillin
- Nefazodone
- Nelfinavir
- Nevirapine
- Octreotide
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Pentobarbital
- Phenobarbital
- Phenytoin
- Posaconazole
- Primidone
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Ritonavir
- Saquinavir
- Secobarbital
- St. John’s Wort, Hypericum perforatum
- Telithromycin
- Thiopental
- Tipranavir
- Tucatinib
- Voriconazole
