Avelumab Brand Name– BAVENCIO
What is Avelumab
Avelumab is a human IgG1 lambda monoclonal antibody that binds to the programmed death ligand-1 (PD-L1) found on T-cells and blocks the interaction of PD-L1 with PD-1 and B7.1 receptors on the tumor cell.
It is indicated for the treatment of metastatic Merkel cell carcinoma, advanced renal cell carcinoma, and certain types of urothelial carcinoma.
Immune-mediated adverse reactions including colitis, pneumonitis, hepatitis, endocrinopathies, and nephritis have been reported with avelumab therapy in clinical trials; treatment with high-dose corticosteroids may be necessary for patients who develop immune-mediated toxicity.
Indications
- Merkel cell carcinoma
- renal cell cancer
- urothelial carcinoma
Side Effects
- abdominal pain
- acneiform rash
- adrenocortical insufficiency
- anemia
- anorexia
- antibody formation
- arthralgia
- arthralgia
- asthenia
- back pain
- bone pain
- bullous rash
- chills
- colitis
- constipation
- cough
- cystitis
- dehydration
- diabetes mellitus
- diabetic ketoacidosis
- diarrhea
- dizziness
- dysphonia
- dyspnea
- elevated hepatic enzymes
- erythema
- erythema multiforme
- exfoliative dermatitis
- fatigue
- fever
- flushing
- GI obstruction
- Guillain-Barre syndrome
- headache
- heart failure
- hematuria
- hepatitis
- hepatotoxicity
- hyperamylasemia
- hyperbilirubinemia
- hypercholesterolemia
- hyperglycemia
- hyperkalemia
- hypertension
- hyperthyroidism
- hypertriglyceridemia
- hyponatremia
- hypophysitis
- hypopituitarism
- hypotension
- hypothyroidism
- ileus
- infection
- infusion-related reactions
- interstitial nephritis
- lymphopenia
- maculopapular rash
- malaise
- musculoskeletal pain
- myalgia
- myocardial infarction
- myocarditis
- nausea
- neutropenia
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- pancreatitis
- pericardial effusion
- peripheral edema
- pneumonitis
- pruritus
- psoriasis
- pyuria
- rash
- renal failure (unspecified)
- stomatitis
- thrombocytopenia
- thromboembolism
- uveitis
- vomiting
- weight loss
Monitoring Parameters
- blood glucose
- LFTs
- serum creatinine
- thyroid function tests (TFTs)
Contraindications
- adrenal insufficiency
- autoimmune disease
- breast-feeding
- cardiac disease
- colitis
- contraception requirements
- diabetes mellitus
- diabetic ketoacidosis
- heart failure
- hepatic disease
- hepatitis
- hepatotoxicity
- hyperlipidemia
- hypertension
- hyperthyroidism
- hypothyroidism
- immune-mediated reactions
- immunosuppression
- infusion-related reactions
- myocardial infarction
- organ transplant
- pneumonitis
- pregnancy
- renal impairment
- reproductive risk
- thyroid disease
- type 1 diabetes mellitus
Interactions
- Palifermin
- Penicillamine
- Tuberculin Purified Protein Derivative, PPD
