Avatrombopag

Avatrombopag Brand Name– DOPTELET

What is Avatrombopag

Avatrombopag is an oral thrombopoietin (TPO) receptor agonist indicated for the treatment of thrombocytopenia in patients with chronic liver disease scheduled to undergo a medical or dental procedure or with chronic immune thrombocytopenia (ITP) who have had an insufficient response to previous treatment.

TPO agonists have been associated with thrombotic and thromboembolic complications.

Avatrombopag should not be administered to patients with either condition in an attempt to normalize platelet counts.

Indications

  • chronic liver disease-associated thrombocytopenia
  • immune thrombocytopenic purpura (ITP)

Side Effects

  1. abdominal pain
  2. anemia
  3. arthralgia
  4. bleeding
  5. epistaxis
  6. fatigue
  7. fever
  8. headache
  9. hyponatremia
  10. infection
  11. myalgia
  12. nausea
  13. peripheral edema
  14. petechiae
  15. pharyngitis
  16. thromboembolism
  17. thrombosis

Monitoring Parameters

  • platelet count

Contraindications

  • breast-feeding
  • hepatic disease
  • pregnancy
  • protein C deficiency
  • protein S deficiency
  • thromboembolism

Interactions

  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Amiodarone
  • Amobarbital
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Bosentan
  • Butabarbital
  • Carbamazepine
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Enzalutamide
  • Fluconazole
  • Fosphenytoin
  • grapefruit juice
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Lopinavir; Ritonavir
  • Mephobarbital
  • Methohexital
  • Mifepristone
  • Ombitasvir; Paritaprevir; Ritonavir
  • Pentobarbital
  • Phenobarbital
  • Phenytoin
  • Primidone
  • Rifampin
  • Rifapentine
  • Ritonavir
  • Secobarbital
  • St. John’s Wort, Hypericum perforatum
  • Thiopental
  • Voriconazole
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