Adapalene and Benzoyl Peroxide Brand Name– Epiduo
What is Adapalene and Benzoyl Peroxide
Adapalene and benzoyl peroxide is a topical gel for the treatment of acne. Adapalene is a topical retinoid-like drug.
Benzoyl peroxide (BPO) exhibits antibacterial activity and has drying actions, sebostatic effects, and causes mild skin desquamation. Benzoyl peroxide improves both inflammatory and non-inflammatory acne lesions.
Current acne treatment guidelines recommend the use of combination therapy with a topical retinoid and an antimicrobial agent; however, there are relatively few fixed-dose combination products available; adapalene 0.1% and benzoyl peroxide 2.5% topical gel represents the first topical retinoid and benzoyl peroxide fixed-dose combination product.
Once daily application of adapalene benzoyl peroxide gel has demonstrated greater efficacy and a faster onset of action than either agent alone.
Adapalene and benzoyl peroxide was FDA-approved in December 2008.
Indications
- acne vulgaris
- Propionibacterium acnes
Side Effects
- atopic dermatitis
- blepharedema
- conjunctivitis
- contact dermatitis
- erythema
- erythema
- erythema
- photosensitivity
- pruritus
- rash
- skin discoloration
- skin irritation
- xerosis
- xerosis
- xerosis
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- accidental exposure
- breast-feeding
- eczema
- pregnancy
- skin abrasion
- sunburn
- sunlight (UV) exposure
Interactions
- Aminolevulinic Acid
- Clindamycin; Tretinoin
- Dapsone
- Fluocinolone; Hydroquinone; Tretinoin
- Halobetasol; Tazarotene
- Hydroquinone
- Isotretinoin
- Mequinol; Tretinoin
- Methoxsalen
- Photosensitizing agents (topical)
- Porfimer
- Salicylic Acid
- Sodium Thiosulfate; Salicylic Acid
- Tazarotene
- Topical Local Anesthetics
- Tretinoin, ATRA
- Trifarotene
- Verteporfin
