Acetohydroxamic Acid Brand Name – Lithostat
What is Acetohydroxamic Acid
Acetohydroxamic acid is an oral agent used as an adjunct in the treatment of chronic urea-splitting urinary tract infections and has been used as last-line adjunct agent for hepatic encephalopathy.
Acetohydroxamic acid inhibits the hydrolysis of urea, decreases the production of ammonia, and decreases urinary pH in urine infected with urea-splitting organisms.
Acetohydroxamic acid should not be considered an acidifying agent nor does it have any direct antimicrobial effect.
Acetohydroxamic acid (Lithostat) was FDA-approved in 1983.
Indications
- nephrolithiasis
- urinary tract infection (UTI)
For use as an adjunct to appropriate anti-infective and surgical therapy in patients with chronic urinary tract infection (UTI) caused by urease-producing bacteria, including patients with struvite nephrolithiasis
Side Effects
- alopecia
- anemia
- anorexia
- anxiety
- depression
- fatigue
- headache
- hemolytic anemia
- leukopenia
- maculopapular rash
- malaise
- nausea
- palpitations
- phlebitis
- pulmonary embolism
- thrombocytopenia
- thrombosis
- tremor
- vomiting
Monitoring Parameters
- CBC
- hemoglobin/hematocrit
- LFTs
- reticulocyte count
- serum creatinine
- urinalysis
Contraindications
- anemia
- breast-feeding
- children
- hemolytic anemia
- hepatic disease
- infants
- leukopenia
- neonates
- pregnancy
- premature neonates
- renal failure
- renal impairment
- thrombocytopenia
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Antacids
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Calcium Carbonate; Magnesium Hydroxide
- Choline Salicylate; Magnesium Salicylate
- Colchicine
- Colchicine; Probenecid
- Ethanol
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- food
- Iron
- Iron Salts
- Magnesium Hydroxide
- Magnesium Salicylate
- Methadone
- Polysaccharide-Iron Complex
- Salsalate
- Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
