Vamorolone – Description Indications & Dosage General dosage information: For the treatment of Duchenne muscular dystrophy (DMD) The FDA has designated vamorolone as an orphan drug for this indication. Oral dosage Adults weighing more than 50 kg: 6 mg/kg PO once daily. The maximum daily dose is 300 mg. The dose may be decreased to a minimum of …
Velmanase Alfa – Description Indications & Dosage For the treatment of non-central nervous system manifestations of alpha-mannosidosis NOTE: The FDA has designated velmanase alfa as an orphan drug for this indication. Intravenous dosage Adults: 1 mg/kg/dose IV once weekly.68624 Children and Adolescents: 1 mg/kg/dose IV once weekly.68624 Maximum Dosage Limits: •Adults 1 mg/kg/dose IV once weekly. …
Atogepant – Introduction Indications & Dosage Guideline indications for initiating migraine prevention with calcitonin gene-related peptide (CGRP) receptor antagonists: 70645 For migraine prophylaxis for episodic migraine prophylaxis Oral dosage Adults: 10, 30, or 60 mg PO once daily. Coadministration of certain other drugs may need to be avoided or dosage adjustments may be necessary; review drug interactions.67011 Guidelines classify …
Landiolol – Introduction Indications & Dosage General Dosing Information Transitioning from landiolol to alternative medications For the treatment of supraventricular tachycardia (SVT), including atrial flutter and atrial fibrillation, for the short-term reduction of ventricular rate for the treatment of SVT with normal cardiac function Intravenous dosage Adults: 9 mcg/kg/minute continuous IV infusion, initially. Titrate by 9 mcg/kg/minute every 10 minutes …
Arimoclomol – Introduction Indications & Dosage For the treatment of neurological manifestations of Niemann-Pick disease type C (NPC) in combination with miglustat NOTE: Arimoclomol is designated as an orphan drug by the FDA for this indication. Oral dosage Adults weighing more than 55 kg: 124 mg PO 3 times a day.71253 Adults weighing 31 to 55 kg: 93 …
Acoramidis – Introduction Indications For the treatment of wild type or variant transthyretin amyloid cardiomyopathy for the reduction of cardiovascular mortality and cardiovascular-related hospitalization Note: Acoramidis is designated as an orphan drug by the FDA for this indication Oral dosage Adults: 712 mg PO twice daily.71564 Maximum Dosage Limits: •Adults 1424 mg/day PO. •Geriatric 1424 mg/day PO. •Adolescents Safety and …
Carbamazepine Toxicity – 13 Interesting Facts Alarm Signs and Symptoms Introduction Table 1. Pharmacokinetic properties of carbamazepine.4 Absorption LipophilicSlow and unpredictable absorption after oral administrationBoth peripheral and central nervous system peak concentrations can be delayed up to 100 hours after overdose ingestionBioavailability approaches 100% with immediate-release preparations, while extended-release formulations are absorbed more slowly and less completely …