Ezetimibe Brand Name– Zetia What is Ezetimibe Ezetimibe is an oral antilipemic agent, approved for use as monotherapy or in combination with HMG-CoA reductase inhibitors (‘statins’) or fenofibrate for the treatment of hypercholesterolemia. It is the first available 2-azetidinone compound, a potent cholesterol absorption inhibitor. Ezetimibe selectively blocks the intestinal absorption of cholesterol and related …
Exenatide Brand Names- Bydureon | Bydureon BCise | Byetta What is Exenatide Exenatide is a subcutaneously administered 39-amino acid glucagon-like peptide-1 agonist (GLP-1 RA) isolated from the salivary gland venom of the lizard Heloderma suspectum (Gila monster). Exenatide was the first agent FDA-approved in the incretin mimetics class. Incretins are endogenous compounds, such as glucagon-like peptide-1 (GLP-1), that improve …
Exemestane Brand Name– Aromasin What is Exemestane Exemestane is an irreversible, steroidal aromatase inhibitor. Exemestane is used in postmenopausal women as second-line hormonal therapy of advanced breast cancer and as adjuvant therapy in postmenopausal women with estrogen-receptor positive early breast cancer. An advantage of exemestane is the lack of cross-resistance with other non-steroidal aromatase inhibitors, …
Evolocumab Brand Name– REPATHA What is Evolocumab Evolocumab is a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor indicated as an adjunct treatment to diet, alone or in combination with other lipid-lowering therapies (e.g., statins, ezetimibe), in adults with primary hyperlipidemia (including heterozygous familial hypercholesterolemia) or for adjunct treatment to diet and other low density lipoprotein …
Everolimus Brand Names- Afinitor | Afinitor DISPERZ | Zortress What is Everolimus Everolimus is a macrolide immunosuppressant and analog of sirolimus that inhibits mammalian target of rapamycin (mTOR), a serine-threonine kinase, downstream of the PI3K/AKT pathway. The mTOR pathway is dysregulated in many human cancers and in tuberous sclerosis complex (TSC). Inhibition of mTOR has been shown …
Etravirine Brand Name– Intelence What is Etravirine Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of human immunodeficiency virus (HIV). It is indicated for use with other antiretroviral medications to treat HIV-1 infections in treatment-experienced adult and pediatric patients 2 years of age and older. Etravirine must be administered after a meal to improve absorption. …
Etoposide VP 16 Brand Names- Etopophos | Toposar | VePesid What is Etoposide VP 16 Etoposide is available as an injectable or a liquid-filled, soft gelatin capsule formulation. Etopophos (etoposide phosphate) is an IV prodrug that is converted to etoposide by dephosphorylation. Etoposide works by causing induction of DNA strand breaks by an interaction with DNA-topoisomerase II …