What is the history of topical medications as analgesics? For centuries, topical analgesics have been used to treat various medical conditions and pain. One of the most famous books in the history of medicine, Avicenna’s Canon of Medicine , originally published in 1025, provides an extensive list of substances to treat headache. Most of these substances included …
Potential central nervous system side effects associated with NSAIDS All NSAIDs have the potential to produce central nervous system side effects, including sedation, dizziness, and headaches. Headaches occur in about 10% of patients taking indomethacin. Usually side effects are mild and transient.
Cardiovascular issues associated with selective COX2 inhibitors NSAIDs and coxibs do not provide the same protective effects as low-dose aspirin. Coxibs (selective COX2 inhibitors) decrease vascular prostacyclin (PGI2) production and may affect the balance between prothrombotic and antithrombotic eicosanoids. However, the available studies can suggest only that there is a potential increase in cardiovascular events …
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What are the documented precautions with celecoxib? Celecoxib is contraindicated in patients who have had an allergic-type reaction to sulfonamide drugs. This agent is not recommended for patients with severe hepatic insufficiency or advanced renal disease. In postmarketing studies, patients receiving celecoxib concurrently with warfarin experienced bleeding events in association with an increase in prothrombin …
Do the selective COX2 inhibitors have a lower risk for gastrointestinal toxicity compared to the traditional nonsteroidal antiinflammatory drugs? Yes. The COX2 inhibitors were associated with a lower incidence of symptomatic ulcers compared with traditional NSAIDs at standard doses. The decrease in upper GI toxicity was strongest among patients not taking aspirin concomitantly.
What is the role of protective therapies in association with administration of traditional nonsteroidal antiinflammatory drugs? To date, only misoprostol has been proved to reduce the risk for serious GI toxicity. Misoprostol diminishes the incidence of endoscopically detectable lesions. However, no evidence has confirmed that misoprostol diminishes the risk of complications from the lesions when …
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What are the potential risk factors for the traditional NSAIDS associated gastrointestinal toxicity • Advancing age • Concomitant administration of corticosteroids • History of either ulcer disease or prior GI complications from NSAIDs