Biologics

What biologic and oral small molecule therapies have been evaluated for use in SLE? Other biologics including TNF inhibitors, abatacept, epratuzumab, tabalumab, ocrelizumab, and tocilizumab have had mixed or negative results when used in SLE patients. Monoclonal antibodies against type I IFNs (e.g., IFNα) and the type I IFN receptor are currently under investigation but …

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Most common Biologics Used to Treat Systemic Lupus Erythematosus Drug Mechanism of Action Dose Indication Belimumab (Benlysta) Monoclonal antibody that inhibits B-lymphocyte stimulator, which modulates B-cell growth and survival 10 mg/kg intravenous monthly200 mg subcutaneous weekly • Has been used as an “add on” for patients who have not fully responded to other therapies.• Consider for musculoskeletal …

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What is Aralast NP Aralast NP is Human Alpha1-Proteinase Inhibitor also known as alpha1–antitrypsin. ARALAST NP is a similar product to ARALAST, containing the same active components of plasma α1-PI with identical formulations. Brand Name Aralast NP Indications Indicated for chronic augmentation therapy in patients having congenital deficiency with clinically evident emphysema. Side Effects pharyngitis …

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What is Gintuit Gintuit is an Allogeneic Cultured Keratinocytes and Fibroblasts in Bovine Collagen Cellular Sheet for Topical Oral Application Brand Name Gintuit Indications Gintuit is an allogeneic cellularized scaffold product indicated for topical (non-submerged) application to a surgically created vascular wound bed in the treatment of mucogingival conditions in adults. Hypovolemia Side Effects Sinusitis …

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What is Ragwitek Ragwitek is Short Ragweed Pollen Allergen Extract Tablet for Sublingual Use . Short ragweed pollen allergen extract is a sublingual immunotherapy (SLIT) approved for the treatment of allergic rhinitis with or without conjunctivitis that is induced by short ragweed pollen in adults aged 18—65 years Brand Name Ragwitek Indications Immunotherapy for the …

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What is Oralair Oralair is Sweet Vernal, Orchard, Perennial Rye, Timothy, and Kentucky Blue Grass Mixed Pollens Allergen Extract Tablet for Sublingual Use Brand Name Oralair Indications ORALAIR is an allergen extract indicated as immunotherapy for the treatment of grass pollen-induced allergic rhinitis with or without conjunctivitis confirmed by positive skin test or in vitro …

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What is Odactra (Dermatophagoides farinae and Dermatophagoides pteronyssinus Allergen Extract) Odactra is Dermatophagoides farinae and Dermatophagoides pteronyssinus Allergen Extract Tablet for Sublingual Use Brand Name Odactra Indications Immunotherapy for house dust mite (HDM)-induced allergic rhinitis, with or without conjunctivitis, confirmed by in vitro testing for IgE antibodies to Dermatophagoides farinae or Dermatophagoides pteronyssinus house dust …

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