Alexia without agraphia

Alexia without agraphia

What is alexia without agraphia and where is the lesion responsible for it? 

Alexia without agraphia (pure word blindness or acquired pure alexia) is the inability to read despite preserved ability to write.

It is associated with a lesion in the dominant occipital lobe (frequently producing a homonymous hemianopia), and a disconnection of the nondominant occipital lobe from the dominant parietal lobe via a lesion of the inferior splenium of the corpus callosum.

Alternately, it can occur with lesions of the dominant lateral geniculate body and splenium of the corpus callosum or with a single lesion of the dominant occipitotemporal periventricular white matter behind, beneath, and beside the occipital horn of the lateral ventricle.

It is most often associated with infarction in the distribution of the dominant hemispheric posterior cerebral artery.


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