Yamaguchi classification criteria
Several criteria have been proposed with the Yamaguchi criteria being most commonly used. Five or more criteria including two or more major criteria yields a 96% sensitivity and 92% specificity to classify a patient as having AOSD.
Yamaguchi classification criteria
- • Major criteria
- – Fever >39°C for >7 days
- – Arthralgias or arthritis ≥2 weeks
- – Characteristic rash
- – Leukocytosis (≥10,000/μL with ≥80% neutrophils)
- • Minor criteria
- – Sore throat
- – Lymphadenopathy
- – Hepatomegaly or splenomegaly
- – Abnormal aminotransferase
- – Negative rheumatoid factor and antinuclear antibody
Exclusion: malignancy (especially lymphoma), infection (especially Epstein–Barr virus), other connective tissue diseases (especially vasculitis, SLE), Sweet’s syndrome, Schnitzler syndrome, familial autoinflammatory syndromes, and drug reactions.
