Which systemic diseases cause predominantly a demyelinating peripheral neuropathy? An axonal peripheral neuropathy?
In most rheumatologic conditions wherein neuropathy is present, the axons are primarily affected, though myelin is rarely completely normal. Demyelination may predominate in a few disorders, such as acute inflammatory demyelinating polyneuropathy (Guillain–Barré syndrome), chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy, anti-myelin-associated glycoprotein antibody syndrome, and other paraproteinemias, and some hereditary neuropathies, such as Charcot–Marie–Tooth disease type 1A.
