What cellular alterations lead to neurological disease

What cellular alterations lead to neurological disease or affect management/prognosis?

  • Loss of neurons (e.g., neurodegenerative conditions)
  • Injury of axons (e.g., traumatic brain injury)
  • Reorganization of synaptic connections (e.g., deafferentation pain)
  • Disruption of the blood–brain barrier (BBB) (e.g., stroke)

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