What causes Tumor lysis syndrome?
Tumor lysis syndrome is usually caused by chemotherapeutic agents in patients with cancer resulting in rapid cell necrosis.
Common agents implicated include cisplatin, etoposide, fludarabine, cytosine arabinoside, methotrexate, paclitaxel, rituximab, and corticosteroids.
Radiation therapy may rarely cause TLS.
Occasionally spontaneous TLS may arise in rapidly growing tumors that outgrow their blood supply.
