Types of dopamine receptors
How many types of dopamine receptors have been identified?
Five dopamine receptors, D1–D5, have now been pharmacologically characterized and cloned.
The receptors are classified into either the D1-like receptor family or the D2-like receptor family, based upon morphological, pharmaceutical, and functional properties.
The D1 and D5 receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3, and D4 receptors are members of the D2-like family.
The functional significance of this multitude of receptors is not clearly understood.
Activation of the D1 receptors appears to be important in mediating dystonic movements, whereas activation of the D2 receptors may result in chorea.
Clozapine, a specific blocker for the D4 receptor, is an effective dibenzodiazepine antipsychotic agent.
