Treatment of IBD Associated Spondyloarthritis
|Drug||Peripheral SpA||Axial SpA|
Only for sacroiliitis
TNF inhibitors b Vedolizumab c
Only for Type 1
a Nonsteroidal anti-inflammatory drugs (NSAIDs) may exacerbate IBD. Cox-2 selective NSAIDs may be safer.
b tumor necrosis factor (TNF) α inhibitors that are approved and effective include infliximab, adalimumab, golimumab, and certolizumab pegol. Etanercept is ineffective for IBD.
c There have been reports of SpA developing in the setting of vedolizumab.
d Secukinumab should be used with caution in patients with IBD as cases were observed to occur in clinical trials as was worsening of established IBD.