Side effects of anticholinesterases on Neuromuscular Junction
What are the chronic Side effects of anticholinesterases on Neuromuscular Junction?
Chronic excess ACh may also damage the muscle endplate, cause simplification of the postsynaptic folds and loss of AChRs, similar to the endplate changes seen in Myasthenia gravis.
These changes may be superimposed on the primary damage caused by Myasthenia gravis itself.
However, as with cholinergic crises, this complication is rarely seen today because successful primary immunotherapy makes the chronic use of high doses of anticholinesterases unnecessary in most patients.
