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Prognosis of malignant gliomas
Have any clinical factors been shown to be useful in predicting prognosis in malignant (grade III and IV) gliomas?
Younger age, Karnofsky performance score (a scale used to quantify cancer patients’ general well-being and activities of daily life), and larger extent of initial surgical resection have been shown to improve prognosis.
Sources
- Stupp R, Mason WP, van den Bent MJ et al.: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352(10):987-996, 2005.
- Brandsma D, Stalpers L, Taal W, et al.: Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas. Lancet Oncol 9(5):453-461, 2008.
- Wen PY, Macdonald DR, Reardon DA, et al.: Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group. J Clin Oncol 28(11):1963-1972, 2010.
- Cohen MH, Shen YL, Keegan P, et al.: FDA drug approval summary: bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme. Oncologist 14(11):1131-1138, 2009.
