What is the nonendoscopic management of peptic ulcer bleeding?
- IV proton pump inhibitor (PPI) bolus and infusion preendoscopy decreases the number of patients with high-risk stigmata at endoscopy and the need for endoscopic treatment, although it has not been shown to decrease related outcomes, including rebleeding, need for surgery, and mortality.
- Preendoscopy IV PPI is likely to be most beneficial in patients with significant, active bleeding or multiple high-risk features.
