Musculoskeletal disorders associated with familial hyperlipoproteinemia
- • Type I, IV, V: gout is associated with the hypertriglyceridemia seen in these conditions. Type IV patients can have chronic arthralgias.
- • Type II, III: tendinous xanthomas on digital extensor tendons and Achilles tendon. Achilles tendinitis can occur. Tuberous xanthomas on extensor surfaces (elbows, knees, hands) can mimic gouty tophi or rheumatoid nodules.
- • Type II: episodic, acute, migratory inflammatory arthritis resembling acute rheumatic fever can occur in up to 50% of patients. Arthritis resolves in 2 weeks but frequently recurs. Cholesterol crystals are not found in the synovial fluid.
- • Type III: osseous xanthomas in long bones can lead to pathologic fractures.
