Musculoskeletal conditions associated with leprosy

Musculoskeletal conditions associated with leprosy

Are there any musculoskeletal conditions associated with M. leprae (leprosy)?

Erythema nodosum leprosum —It is seen in lepromatous leprosy and probably represents a “reactive” arthritis. Clinical manifestations include fever, subcutaneous nodules, arthralgias, and frank arthritis.

Symmetric polyarthritis —It is usually insidious and involves the wrist, small joints of the hands and feet, and knees. Onset is months to years after initial infection. It is most often seen in tuberculoid or borderline leprosy. May be rheumatoid factor-positive.

Bony abnormalities secondary to neuropathy—These include resorption of the distal metatarsals, aseptic necrosis, “claw” hands, and Charcot joints.

Direct infection of the bone—This typically affects the distal phalanges.

Lucio’s phenomenon —Necrotizing vasculitis of skin due to lepromatous leprosy.


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