Lymphomatous kidney infiltration (LKI)

What is lymphomatous kidney infiltration (LKI)?

Lymphomatous kidney infiltration is common, albeit underdiagnosed, among patients with cancer.

In most studies, Lymphomatous kidney infiltration was found to have a high incidence. While the incidence is high, the association with kidney failure is low.

The mechanism of LKI-induced AKI is not completely established. The tubules and glomeruli usually appear morphologically normal on biopsy; it has been proposed that interstitial and intraglomerular pressure elevation due to lymphocytic infiltrations of these compartments is the underlying mechanism of the AKI.

Diagnosis can be made via a kidney ultrasound and computed tomography scan imaging in some cases, but a kidney biopsy is required for a definite diagnosis.

The management of LKI is focused on the treatment of the underlying malignancy.

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