What is lymphomatous kidney infiltration (LKI)?
Lymphomatous kidney infiltration is common, albeit underdiagnosed, among patients with cancer.
In most studies, Lymphomatous kidney infiltration was found to have a high incidence. While the incidence is high, the association with kidney failure is low.
The mechanism of LKI-induced AKI is not completely established. The tubules and glomeruli usually appear morphologically normal on biopsy; it has been proposed that interstitial and intraglomerular pressure elevation due to lymphocytic infiltrations of these compartments is the underlying mechanism of the AKI.
Diagnosis can be made via a kidney ultrasound and computed tomography scan imaging in some cases, but a kidney biopsy is required for a definite diagnosis.
The management of LKI is focused on the treatment of the underlying malignancy.