Lab abnormalities seen in Lyme disease

laboratory abnormalities that may be seen in Lyme disease

In patients with CNS involvement (neuroborreliosis), cerebrospinal fluid (CSF) analysis typically shows a lymphocytic pleocytosis, mildly elevated protein concentration (100–200 mg/dL) and normal glucose concentration. Additionally, a high IgG index and oligoclonal bands may be present. Specific testing includes intrathecal antibodies against Borrelia . The most sensitive and specific application of this test is through the calculation of an antibody index (the ratio of Borrelia /total antibody in the CSF versus the same ratio in the serum). PCR testing of CSF may also be performed, but the sensitivity is very low (<20%).

During episodes of arthritis, synovial fluid white cell counts range from 500 to 110,000/mm 3 , with a polymorphonuclear predominance. PCR has detected B. burgdorferi DNA in synovial fluid and synovial tissue in research settings, but it is not used routinely in clinical practice.


Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

Scroll to Top