Is there an effective treatment for Kawasaki Disease?
Intravenous immune globulin (IVIG) at a dose of 2 g/kg given over 10–12 hours is the treatment of choice for acute KD. This is more effective in preventing persistent coronary artery aneurysms if given within the first 10 days after the disease onset. IVIG is given in conjunction with high-dose aspirin (30–50 or 80–100 mg/kg per day in 4 divided doses). Once the fever has resolved, the dose of aspirin is decreased to a single oral dose of 3–5 mg/kg per day for its antiplatelet effect. In those who do not develop coronary artery abnormalities, the aspirin can be discontinued 6 weeks after treatment and when the ESR, CRP, and platelet counts have normalized.