What is the spectrum of immune related adverse events seen with ICPIs?
Immune-related adverse events (IRAEs) affect multiple organs and systems, including the skin, gastrointestinal (GI) tract, heart, lungs, kidneys, eyes, musculoskeletal system, nervous system, hematologic system and the endocrine system.
| ADVERSE EVENT | ONSET | DURATION |
| Pruritis, Rash | 3–4 weeks | 7–8 weeks |
| Colitis, Diarrhea | 4–6 weeks | 5–6 weeks |
| Hepatic Toxicity | 6–8 weeks | 7–8 weeks |
| Hypophysitis | 6–8 weeks | Permanent (usually) |
