How to determine if a patient with gout is an overproducer or underexcreter of uric acid?
Although not routinely required in clinical management, a 24-hour urine collection can be obtained to determine uric acid and creatinine excretion (the latter to ensure an adequate 24-hour collection). On a regular purine diet, a urate value >800 mg/24 hours suggests overproduction, whereas a value <800 mg suggests underexcretion.
