How to detect myeloma induced kidney disease after finding a monoclonal protein or in a person with newly found kidney impairment ?
Of people older than 70 years, 3% have MGUS; this age group also has a high disease prevalence of diabetes and hypertension. Therefore, screening for alternative causes for kidney dysfunction in this age group will find patients with MGUS. The duration of the clinical history of kidney impairment and the extent of diabetic complications are helpful in differentiating the cause. In general, patients with MGUS have low levels of monoclonal protein (<3 g/dL), a normal FLC ratio, an absence or low level of urine LCs, and no clinical evidence of myeloma (no osteolytic lesions, anemia, or hypercalcemia). In some cases, bone marrow or kidney biopsy may be required.
